HEXOKINASES IN BREAST CANCER

S. Kharitonov (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences)
A. Zikiriahodzhaev (National Medical Research Radiological Center, Ministry of Health of the Russian Federation)
M. Ermoshchenkova (National Medical Research Radiological Center, Ministry of Health of the Russian Federation)
A. Sukhot’ko (National Medical Research Radiological Center, Ministry of Health of the Russian Federation)
M. Fedorova (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences)
E. Pudova (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences)
B. Alekseev (National Medical Research Radiological Center, Ministry of Health of the Russian Federation)
A. Kaprin (National Medical Research Radiological Center, Ministry of Health of the Russian Federation)
A. Kudryavtseva (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences & National Medical Research Radiological Center, Ministry of Health of the Russian Federation)

International Journal of Biosciences and Biotechnology
Vol 4 No 2 (2017)

Hexokinases are one of the key enzymes involved in the process of glycolysis. The level of expression of hexokinases is widely studied in breast cancer as a possible marker of unfavorable prognosis and aggressiveness of tumors. The level of expression of hexokinase may reflect the level of glycolysis activation and, thus, indicate samples with the most altered cellular metabolism.