Two Flavonoid Compounds as Antiproliferative Activity Against SP-C1 Cancer Tongue Cells from the Leaves of Rasamala (Altingia excelsa Nornha)

Risyandi Anwar (Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Muhammadiyah, Semarang 50273, Central Java, Indonesia.)
Arlette Setiawan (Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia.)
Supriatno Supriatno (Departemen Kimia FakulDepartment of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Jogjakarta 50125, Indonesia.)
Unang Supratman (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia. Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia)

VALENSI
Jurnal Kimia VALENSI Volume 4, No. 2, November 2018

Two flavonoid compounds, kaempferol (1) and quercetin (2) have been isolated from the leaves of Rasamala (Altingia excelsa Nornha). The chemical structure of compounds 1 and 2 were identified by spectroscopic evidences including, UV, IR, 1D-NMR, 2D-NMR and MS as well as by comparing with previously reported spectral data.These compounds were isolated from this plant for the first time. Compounds 1 and 2 were evaluated for their antiproliferative activity against SP-C1 cancer tongue cells and showed IC50 values of 2.50 and 2.31 mM, respectively.