INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
Vol. 6, No. 1 Januari 2012

TOPICAL APPLICATION OF ETHANOL EXTRACT OF STARFRUIT LEAVES (AVERRHOA BILIMBI LINN) INCREASES FIBROBLASTS IN GINGIVAL WOUNDS HEALING OF WHITE MALE RATS

Hartini, IGAA (Unknown)



Article Info

Publish Date
27 Nov 2012

Abstract

ABSTRACT Injuries to the gingiva are often encountered because of abnormalities in the oral cavity. Gingival wound healing is more complex because it lies in an open area, often contaminated and exposed to various types of bacteria in the oral cavity. Gingiva wound healing is determined by increase of fibroblasts. Plants widely used by humans as medicine is star fruit (Averrhoa Bilimbi Linn). This study aims to determine an increase of gingival fibroblasts on wound healing of male white rats given various concentrations of starfruit leaves extract topically. The study was conducted with a pretest-posttest control group design, consisted of four groups: the control group with distilled water and the groups treated with ethanol extract of starfruit leaves with a concentration of 10%, 20% and 40%. The result based on comparison test between the groups with One Way Anova, showed that the average amount of fibroblast in four groups after receiving the treatment was significantly different (p<0.01). The result of the test showed an increase in the number of fibroblasts in groups concentration of 10% and 20%, there was a decline observed in group concentration of 40%. It was concluded that application of ethanol extract of starfruit leaves with concentration of 10% increase the highest number of fibroblasts in the rat gingival wound healing process.

Copyrights © 2012






Journal Info

Abbrev

ijbs

Publisher

Subject

Medicine & Pharmacology

Description

Indonesia Journal of Biomedical Science (IJBS), Print-ISSN 2085-4773; E-ISSN 2302-2906 is an international and peer-reviewed journal published twice per year in print and online by Indonesian of Biomedical Association in collaboration to Postgraduate School of Biomedicine Udayana University, ...