TOXICITY ASSESSMENT ON NINE SPONGES SPECIES FROM SPERMONDE ARCHIPELAGO

Ajuk Sapar (Department of Chemistry, Tanjungpura University – Pontianak 78124)
Alfian Noor (Department of Chemistry, Hasanuddin University – Makassar, 90245)
Nunuk Hariani Soekamto (Department of Chemistry, Hasanuddin University – Makassar, 90245)
Ahyar Ahmad (Department of Chemistry, Hasanuddin University – Makassar, 90245)
Tri Aryono Hadi (Division of Marine Resources, Research Center for Oceanography (RCO), LIPI, Jakarta 14430)

MARINA CHIMICA ACTA
Vol. 16 No. 2 (2015): Volume 16 No. 2 (2015)

Toxicity assessment have been conducted on nine sponges species collected from Spermonde Archipelago namely Kapoposang Island, Samalona Island and Lanjukang Island. Toxicity assessment was using Brine Shrimp lethality Test (BST) method againts sponge extracts. Theresults test were expressed as 50% lethal concentration (LC50) to Artemia salina and correlated with prospecting extract potential as anticancer. All extracts obtained from smallscale extraction by methanol. Test results as follows: Acanthostrongylophora ingens (24.830 μg/mL), Hytios erectus (46.140 μg/mL), Stylissa massa (>1000 μg/mL), Theonella sp (35.010 μg/mL), Niphates olemda (87.500 ppm), Haliclona (Reniera) fascigera (78.160 μg/mL), Petrosia (Petrosia) sp (3.008), Callyspongia (Euplacella) biru (0.515 μg/mL). The test results showed that seven species are potential as anticancer with LC50 value ≤ 500 ppm and only Stylissa massa extracts was not potential as anticancer.