Anatomical changes are good indicators used to know influence environmental stress on plant. The objective of this research is to study the multiple stress effect of purple nutsedge (Cyperus rotundus L.) interference and drough on the xylem cell wall thickening of stems, roots and leaves of soybean [Glycine max (L.) Merr.] Var. Grobogan. This research was carried out using two experimental Completely Randomized Designs (CRD) (3X3), i.e. purple nutsedge interference (control, three and six purple nutsedge) and drought stress (control, mild and severe).  The results showed that  multiple stress purple nutsedge interference and drought led to the addition of xylem cell wall thickness of stem, root and leaves .The higher level of interference and drought, xylem cell walls thicker. Keyword : multiple stress, ROS, phenolic compound, lignin, xylem.
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