RANCANGAN D-OPTIMAL MODEL MICHAELIS MENTEN DAN EMAX DENGAN MATLAB

Tatik Widiharih (Jurusan Statistika FSM Undip)
Sri Haryatmi (Jurusan Matematika FMIPA UGM)
Gunardi Gunardi (Jurusan Matematika FMIPA UGM)
Yuciana Wilandari (Jurusan Statistika FSM Undip)

Media Statistika
Vol 8, No 2 (2015): Media Statistika

Michaelis Menten and Emax models  are  widely used in chemistry, pharmacokinetics and pharmacodynamics areas. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model. In this paper will discuss the D-optimal design for Michaelis Menten and Emax models with  homoscedastics  error assumtion.  Determination of D-optimal designs based on Generalied Equivalence Theorem Kiefer-Wolvowitz. We used minimally supported design with the proportion of  each design point is uniform, lower bound of design region is design point and the others are interior points.Keywords: D-optimal, Michaelis Menten, Emax, Minimally Supported Design, Homoscedastics