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Tatik Widiharih
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RANCANGAN D-OPTIMAL MODEL MICHAELIS MENTEN DAN EMAX DENGAN MATLAB Tatik Widiharih; Sri Haryatmi; Gunardi Gunardi; Yuciana Wilandari
MEDIA STATISTIKA Vol 8, No 2 (2015): Media Statistika
Publisher : Department of Statistics, Faculty of Science and Mathematics, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.531 KB) | DOI: 10.14710/medstat.8.2.69-80

Abstract

Michaelis Menten and Emax models  are  widely used in chemistry, pharmacokinetics and pharmacodynamics areas. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model. In this paper will discuss the D-optimal design for Michaelis Menten and Emax models with  homoscedastics  error assumtion.  Determination of D-optimal designs based on Generalied Equivalence Theorem Kiefer-Wolvowitz. We used minimally supported design with the proportion of  each design point is uniform, lower bound of design region is design point and the others are interior points.Keywords: D-optimal, Michaelis Menten, Emax, Minimally Supported Design, Homoscedastics
Co-Authors Gunardi Gunardi Sri Haryatmi Yuciana Wilandari