Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter
Vol 1, No 1 (2011): Life Sciences

The isolation and identification of antimalarial agents of the n-hexane fraction of the neem leaves (Azadirachta indica A. Juss)

. Suryawati (Unknown)
Hanifah Yusuf (Unknown)
. Sofia (Unknown)



Article Info

Publish Date
15 Dec 2011

Abstract

 Abstract. Following the study which confirmed the antimalarial activity of the n-hexane fraction of the neem leaves (Azadirachta indica A.Juss), a research that aimed to reveal the active compounds act as antimalarial agents had been conducted. In this study, the n-hexane fraction of neem leaves were analyzed using the phytochemical, spectroscopic and chromatographic methods.  The chemical compounds, suspected to have an antimalarial activity, were isolated using the thin-layer chromatographic method with several solvents which different in their polarity. The visualizing reagents were used to characterize the compounds. The result showed that the n-hexane fraction of neem leaves contained of steroids, terpenoids and fenols. Analysis by gas chromatography-mass spectroscopy showed that fenol derivatives existed in the largest amount. The compounds were identified as benzyl benzoat (25.63%), tetracosane (17.51%) and hexadecanal (14.61%)

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