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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jurnal Ilmiah Mahasiswa Kedokteran Medisia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Mahasiswa Karakter Bangsa Media Farmasi Indonesia Trends in Infection and Global Health
Hanifah Yusuf
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Respon akut tekanan darah akibat konsumsi kopi pada wanita sehat Yusni, Yusni; Yusuf, Hanifah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 9, No 1 (2020)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.9.1.19-26

Abstract

Background: Coffee contains caffeine. Caffeine is the main component that influences the response of the cardiovascular system and blood pressure (BP). Acute response of coffee to increased BP is related to caffeine.Objectives: This study aims to analyze the acute response of coffee consumption on BP in healthy females therefore coffee is an alternative therapy for hypotension.Methods: The research design was a clinical trial. Treatment: black coffee, Gayo’s Arabica, 10 mg, coffee brewed with 150 ml of boiling water, without sugar. BP was examined using a mercury sphygmomanometer and stethoscope. BP each subject was examined twice and averaged. BP was checked 3 times: before, 30, and 60 minutes after coffee consumption. All subjects were non-coffee drinkers. A total of 20 healthy female, 18-20 years old were divided into two groups: the non-intervention (n=9) and intervention (n=11). Data was analyzed by independent and paired sample t-test.Results: Coffee increased systolic 10-20 mmHg (14.09%) and diastolic 3.64 mmHg. Coffee lowers 36.36% of subjects with hypotension. There was no difference between systolic pre-test (101.11±12.69 vs 100.00±10.00 mmHg; p=0.83) and 30 minutes post-intervention (102.22±13.01 vs 101.82±9.82 mmHg; p=0.94). There were a significant differences in systolic after 60 minutes post-intervention (103.33±11.18 vs 114.09±5.84 mmHg; p=0.01*) between non-intervention and intervention. There was no difference between diastolic pretest (70.00±5.59 vs. 68.18±6.03 mmHg; p=0.49), 30 minutes (70.59±5.27 vs. 70.00±6.33 mmHg; p=0.83), and 60 minutes post-intervention (70.00±5.59 vs. 71.82±4.04 mmHg; p=0.41) between non-intervention and intervention. Data showed that systolic was significantly different (p=0.00*) after 60 minutes of coffee consumption in the intervention group. Conclusion: The acute response of coffee consumption to systolic increases was after 60 minutes and not 30 minutes of coffee consumption. Coffee doesn’t affect diastolic in healthy women, but it needs further research.
Relationship between Physical Activities, Stress and Eating Patterns with the Risk of Hipertension in Women in Baiturrahman Community Health Centers Banda Aceh Sari, Etika; Yusni, Yusni; Usman, Said; Syukri, Maimun; Yusuf, Hanifah
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 3, No 3 (2020): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v3i3.1142

Abstract

The pattern of disease events at this time has experienced a change marked by changes in disease and death that were originally dominated by infectious diseases switch to non-communicable diseases. In the 2018 Riskesdas results the prevalence of hypertension in Aceh increased compared to 2013. Purpose: to find out the factors associated with the incidence of hypertension in women at the Baiturrahman Health Center in Banda Aceh City. Research Methods: This research is a type of quantitative research with cross-sectional study design conducted on 124 samples. Sampling was carried out using the Accidental Sampling technique. Data analysis uses univariate, bivariate and multivariate. Statistical analysis using chi-square and logistic regression. Results: The results showed that there was a significant relationship between family history (p-value = 0.007, OR = 2.8), food consumption patterns (p-value = 0.025, OR = 2.5), obesity status (p-value = 0.046, OR = 2.2), Physical activity (p-value = 0.012, OR = 3.2) and Stress (p-value = 0.017, OR = 2.9) with the incidence of hypertension in women. Multivariate analysis results indicate that family history is a dominant factor in the incidence of hypertension (OR = 4.7). Conclusion: Family history, food consumption patterns, obesity, physical activity and stress are related to the incidence of hypertension and the most dominant factor in the incidence of hypertension in women in the working area of the Baiturrahman Health Center in Banda City is family history of hypertension.
Diagnostic Value of Serum Procalcitonin in Hospitalized Sepsis Patients Cut Murzalina; Bakhtiar Bakhtiar; Hanifah Yusuf; Buchari Buchari
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15738

Abstract

The antimalarial activity of the extract of the neem leaves (Azadirachta indica, A. Juss) on Plasmodium falciparum in vitro Hanifah Yusuf; . Suryawati; . Maryatun
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.337 KB)

Abstract

.  Malaria is a life-threatening disease due to the development of resistance by the most lethal causative parasitic species mainly Plasmodium falciparum. One of a great challenges in malaria controlling program is P.falciparum that has been resistant to the most commonly available antimalarials. New drugs with specific structures and mode of actions are urgently required to treat sensitive and drug-resistant strains of malaria parasites. This study was designed to know the antimalarial activity of the extract of the neem leaves (Azadirachta indica A.Juss) on the growth stages of P. falciparumFCR-3. The experimental laboratoric study used “post-test only with control design”. RPMI 1640 used as culture medium for cultivation of P. falciparum. Treated drug was the extract of neem leaves dissolved in dimethylsulfooxide and prepared into 7 levels concentration (3,125; 6,25; 12,5; 25; 50; 100 and 200 ug/mL). Negative control was culture medium with the malarial parasites. After cultured, synchronized, micromalarialculture were divided into control and treated groups then  incubated in CO2 Candle Jar at 370 C for 72 hour. Each 8 hour the percentage of parasitemia were measured for observing the activity of the extract on the growth stages of P. falciparum. After incubation, supernatant fluid was removed without disturbing the erythrocyte layer. Parasitemia was calculated by made the thin blood smear from the erythrocyte layer and stained with 10% Giemsa for 30 minutes. The antimalarial activity of the extract was calculated by counted the fifty percent of growth inhibition 50 (IC50) using probit analysis. The result showed that the neem leaves extract can inhibit the growth of P. falciparum FCR-3 on mature schizont stage and the fifty percent inhibitory concentration (IC50) of the extract was 3,86 µg/ml after 32 hour incubating. The result indicated that the extract has an antimalarial activity on P. falciparumFCR-3 in vitro
The isolation and identification of antimalarial agents of the n-hexane fraction of the neem leaves (Azadirachta indica A. Juss) . Suryawati; Hanifah Yusuf; . Sofia
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.182 KB)

Abstract

 Abstract. Following the study which confirmed the antimalarial activity of the n-hexane fraction of the neem leaves (Azadirachta indica A.Juss), a research that aimed to reveal the active compounds act as antimalarial agents had been conducted. In this study, the n-hexane fraction of neem leaves were analyzed using the phytochemical, spectroscopic and chromatographic methods.  The chemical compounds, suspected to have an antimalarial activity, were isolated using the thin-layer chromatographic method with several solvents which different in their polarity. The visualizing reagents were used to characterize the compounds. The result showed that the n-hexane fraction of neem leaves contained of steroids, terpenoids and fenols. Analysis by gas chromatography-mass spectroscopy showed that fenol derivatives existed in the largest amount. The compounds were identified as benzyl benzoat (25.63%), tetracosane (17.51%) and hexadecanal (14.61%)
HUBUNGAN KEPATUHAN MINUM OBAT KELASI BESI TERHADAP PERKEMBANGAN SEKS SEKUNDER PADA ANAK PENDERITA Thalasemia Beta Mayor DI SENTRAL THALASEMIA RSUDZA BANDA ACEH Fahmiati Arifna; Jufitriani Ismy; Hanifah Yusuf
Jurnal Ilmiah Mahasiswa Kedokteran Medisia Vol 2, No 3: Agustus 2017
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Medisia

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Abstract

Thalasemia merupakan penyakit yang diturunkan. Pada penderita thalasemia, hemoglobin mengalami penghancuran (hemolisis). Akibatnya penderita harus menjalani pengobatan seumur hidup. Efek dari penyakit dan pengobatan thalasemia adalah terganggunya perkembangan seks sekunder akibat zat besi yang berlebihan. Tujuan dari penelitian ini untuk mengetahui ada tidaknya hubungan antara kepatuhan minum obat kelasi besi dengan perkembangan seks sekunder pada anak penderita thalasemia di Sentral Thalasemia Rumah Sakit dr. Zainoel Abidin (RSUDZA) Banda Aceh. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Pengambilan sampel dilakukan dengan teknik consecutive sampling, didapatkan 43 pasien yang memenuhi kriteria inklusi dari 21 Juli – 30 September 2016. Analisis data penelitian menggunakan uji statistik Mann-Whitney. Hasil penelitian dari 43 pasien - 19 anak laki-laki (44,2%) dan 24 anak perempuan (55,8%) - menunjukkan terdapat hubungan yang signifikan antara kepatuhan minum obat kelasi besi dengan perkembangan seks sekunder (p = 0,010) pada anak penderita thalasemia beta mayor.Thalassemia is an inherited disease. Haemoglobin in thalassemia patient is being dissolved (haemolisis), thus, the people who suffer from thalassemia must get medical treatment for the rest of theirlife. Treatment of thalassemia and the disease itself interfere the development of secondary sexual traits in children suffering from the disease due to excessive iron produced. The aimed of this research is to know the corelation between adherence to iron chelating agent therapy with the development of secondary sexual traits in children with thalassemia at Thalasemia Center of Zainoel Abidin Hospital, Banda Aceh. This is an analitic-observasional research using a cross-sectional design. Sampling technique was done through concecutive sampling. In total, there were 43 patients met the inclusion criterias whom then being included in this study, started from july 27th to september 30th 2016. Data analysis was performed using mann-whitney statistic test. The result of total 43 samples - 19 of whom are boys (44,2%) while the rest 24 are girls (55,8%)- showed that there is a significant relationship between adherence to iron chelating agent therapy with secondary sexual development (p=0.010) in children with beta major thalassemia.
PEMAHAMAN MATERI KETAHANAN NASIONAL TERHADAP KARAKTER DISIPLIN SISWA KELAS X DI SMA PGRI 56 CIPUTAT Hanifah Yusuf
Jurnal Mahasiswa Karakter Bangsa Vol 1, No 1 (2021): Jurnal Mahasiswa Karakter Bangsa Volume 1 No. 1 Maret 2021
Publisher : Jurnal Mahasiswa Karakter Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.526 KB)

Abstract

Setiap siswa masih kurang memahami materi tentang ketahanan nasional sehingga siswa menjadi kurang paham dengan maksimal dalam belajar. Adapun tujuan dari materi ini agar dapat menumbuhkan sikap tanggung jawab siswa dan karakter yang baik. Penelitian ini memiliki tujuan Untuk mengetahui pengaruh Pemahaman Materi Ketahanan Nasional terhadap Karakter Disiplin Siswa kelas X di SMA PGRI 56 Ciputat. Peneliti menggunakan metode penelitian kuantitatif asosiatif yang populasinya ialah  seluruh siswa SMA PGRI 56 Ciputat yang berjumlah 247 peserta didik dan populasi terjangkaunya yaitu peserta didik kelas X yang berjumlah 81 dengan 68 peserta didik yang dijadikan sebagai sampel.Penelitian dengan menggunakan uji t yang telah dilakukan menunjukkan data thitung = 12,04 dan ttabel = 0,26 dengan kriteria pengujian Jika thitung< ttabel maka H0 diterima dan H1 ditolak dan jika thitung ≥ttabel maka H0 ditolak dan H1 diterima. Dengan demikian maka H0 ditolak dan H1 diterima karena thitung> ttabel hal ini berarti Terdapat Pengaruh Yang Signifikan Antara Pemahaman Materi Ketahanan Nasional terhadap Karakter Disiplin Siswa Kelas X di SMA PGRI 56 Ciputat Kata kunci : Pemahaman Materi Ketahanan Nasional, Karakter Disiplin Siswa 
ANALISIS HKSA SENYAWA TURUNAN EURIKUMANON SEBAGAI ANTIMALARIA MENGGUNAKAN PENDEKATAN REGRESI LINIER BERGANDA Hanifah Yusuf; Mustofa; Mahardika Agus Wijayanti; Ratna Asmah Susidarti; Andrian Saputra; Iqmal Tahir
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Quantitative Structure Activity Relationship (HKSA) study of eurycomanone derivatives as antimalarial compound was done using multiple linear regression approaches. HKSA equation was obtained from theoretical descriptors data which involved atomic net charges (q), partition coefficient (log P), molecular volume (VM), molecular surface area (LP), molecular weight (BM), and HOMO-LUMO energy differences (EHOMO-ELUMO) versus minimum concentration to inhibit 50% of parasite growth Plasmodium falciparum (log IC50) growth. Descriptors data were obtained by applying AM1 semiempirical quantum mechanics calculation using Hyperchem 7.5 software, while the regression data processes were runned using SPSS 17.0 program. Based on multiple linear regression approaches, there is a selected quantitative relationship between log IC50 to the descriptors that was shown by HKSA equation below: Log IC50 = – 3048.930 + 5137.957qC2 – 13799.126qC5 – 1537.764qC12 + 556.313qC16 – 817.654qO29 + 4.654log P – 0.146VM + 0.270BM with n =10, r = 0.982, SE = 1.262, Fcalc/Ftable = 17.805, and PRESS = 1.593
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Obat Asam Mefenamat Pada Mahasiswa Universitas Syiah Kuala Hijra Novia Suardi; Amida Jannatus Saleha; Dina Alia; Zahratul Aini; Hanifah Yusuf; Suryawati Suryawati; Vera Dewi Mulia
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.28717

Abstract

Swamedikasi adalah suatu perilaku pemilihan dan penggunaan obat-obatan sendiri yang dilakukan seseorang dalam mengobati gejala penyakit yang dialaminya tanpa menggunakan resep dokter. Jenis obat yang banyak digunakan untuk swamedikasi adalah obat anti nyeri asam mefenamat. Saat ini masih banyak masyarakat yang melakukan praktek swamedikasi secara tidak rasional sehingga menimbulkan masalah seperti efek samping yang berbahaya bagi tubuh. Hal ini dipengaruhi oleh kurangnya pengetahuan masyarakat tentang bagaimana cara melakukan swamedikasi yang tepat, aman, dan rasional. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku swamedikasi obat asam mefenamat pada mahasiswa non kesehatan (Fakultas Hukum) Universitas Syiah Kuala. Penelitian ini merupakan penelitian observasional dengan rancangan cross-sectional. Pengambilan data dilakukan secara online dengan metode proportional random sampling pada mahasiswa Fakultas Hukum Universitas Syiah Kuala. Hasil penelitian dari 104 responden didapatkan sebanyak 52,9% responden memiliki pengetahuan swamedikasi yang cukup dan sebanyak 78,8% responden memiliki perilaku yang cukup mengenai swamedikasi obat asam mefenamat. Hasil uji korelasi Spearman antara pengetahuan dan perilaku didapatkan nilai r=0,032 dan p=0,018 yang menunjukkan adanya hubungan yang signifikan antara tingkat pengetahuan dengan prilaku swamedikasi asam mefenamat dengan korelasi yang lemah pada mahasiswa Fakultas Hukum Universitas Syiah kuala.
Persistence of long COVID symptoms in COVID-19 survivors worldwide and its potential pathogenesis - A systematic review and meta-analysis Fahriani, Marhami; Ilmawan, Muhammad; Fajar, Jonny K.; Maliga, Helnida A.; Frediansyah, Andri; Masyeni, Sri; Yusuf, Hanifah; Nainu, Firzan; Rosiello, Francesco; Sirinam, Salin; Keam, Synat; Ophinni, Youdiil
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.36

Abstract

The study sought to determine the prevalence of persistent long COVID symptoms such as anxiety, depression, dizziness, chest pain, sleep difficulty, palpitations, weight loss, and hair loss among coronavirus disease 2019 (COVID-19) survivors worldwide and to discuss the potential pathogeneses. Potential studies were searched in three databases (PubMed, Scopus, and Web of Science) as of January 30, 2021. Data on study characteristics, patient characteristics during the follow-up, the number of patients with persistent long COVID symptoms and total COVID-19 survivors were collected according to PRISMA guidelines. To assess the quality of studies, the Newcastle-Ottawa scale was used. The estimated prevalence of each long COVID symptom and the association between COVID-19 severity and the occurrence of prolonged symptoms was assessed, if appropriate. The global prevalence of prolonged anxiety was 15.76% (95%CI: 6.36%, 25.15%). Chest pain persisted in 10.36% (239/3,224) of COVID-19 patients (95%CI: 4.92%, 15.80%). Prolonged depression was found in 24 of 548 COVID-19 survivors with an estimated prevalence of 4.32% (95%CI: 2.62%, 6.03%) and dizziness was presented in 4.83% (118/2,219, 95%CI: 1.50%, 8.16%) after recovery. Hair loss was complained by 527 of 2,251 recovered patients (cumulative prevalence of 24.76%, 95%CI: 19.60%, 29.91%), while weight loss was identified in 37 cases among 452 COVID-19 survivors (8.19%, 95%CI: 5.66%, 10.71%). Prolonged palpitation was experienced by 19.38% (211/1,926) survivors with 95%CI: 2.40%, 41.16%. Sleep difficulty was found in 541 of 2,622 COVID-19 survivors (17.87%, 95%CI: 7.55%, 28.20%). The association between COVID-19 severity and the occurrence of persistent long COVID symptoms was not analyzed due to the lack of data. In conclusion, persistent psychological symptoms are frequently reported among COVID-19 survivors. Follow-up studies with a longer duration and larger population are warranted to assess the extent of prolonged symptoms and the quality of life of COVID-19 survivors. Despite various potential pathogeneses that have been hypothesized, a definitive mechanism is yet to be addressed.
Co-Authors . Maryatun . Sofia . Suryawati . Vera Dewi Mulia, Troef Soemarno Amida Jannatus Saleha Andri Frediansyah, Andri Andrian Saputra Buchari Buchari Cut Murzalina Dina Alia ENDANG MUTIAWATI, ENDANG Fahmiati Arifna Fahriani, Marhami Fajar, Jhonny K. Feliatra Firzan Nainu Hijra Novia Suardi Husnah, Milda Ilmawan, Muhammad Iqmal Tahir Jonny K. Fajar Jufitriani Ismy Keam, Synat Mahardika Agus Wijayanti Maimun Syukri, Maimun Maliga, Helnida A. Mamada, Sukamto Masyeni, Sri Maya Sari Murzalina, Cut Mustofa Mustofa Novia, Hijra Ophinni, Youdiil Ratna Asmah Susidarti Rosa, Sandro GV. Rosiello, Francesco Safrizal Rahman, Safrizal Sari, Etika Sirinam, Salin Suryawati Suryawati Usman, Said Yusni Yusni Yusni Yusni Zahratul Aini