<![CDATA[Oocyte maturation is mediated by active Maturation  Promoting Factor (MPF) in ooplasma. Maturation Promoting Factor (MPF) is heterodimer protein consists of sub catalytic unit p34cdc2 and sub regulatorunit of cyclin-B. The regulation of maturation promoting factor (MPF) occures throught phosphorylation and dephosphorilation Cdc2 while its activities are controlled by the accumulation and periodical degradation from Cyclin-B during cell cycles development. Leptin inknown has role on oocyte maturation that works at mitogen activated protein kinase (MAPK). MAPK belongs to protein kinase family Ser/Thr that interact with MPF in arranging the progresivennes of oocyte meiosis through the help of c-mos. This interaction is initiated phosphorilation of Ser-369 and Thr-577 in p90rsk. Key words:leptin, MPF, and oocyte maturation.]]>
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