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All Journal Jurnal Kedokteran Brawijaya
Rasyad Indra
Laboratorium Ilmu Faal Fakultas Kedokteran Universitas Brawijaya Malang
Medicine & Pharmacology

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PERAN LEPTIN TERHADAP AKTIVITAS MATURATION-PROMOTING FACTOR(MPF) PADA MATURASI OOSIT Kakisina, Pieter; Indra, Rasyad
Jurnal Kedokteran Brawijaya Vol 24, No 1 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.213 KB) | DOI: 10.21776/ub.jkb.2008.024.01.5

Abstract

Oocyte maturation is mediated by active Maturation  Promoting Factor (MPF) in ooplasma. Maturation Promoting Factor (MPF) is heterodimer protein consists of sub catalytic unit p34cdc2 and sub regulatorunit of cyclin-B. The regulation of maturation promoting factor (MPF) occures throught phosphorylation and dephosphorilation Cdc2 while its activities are controlled by the accumulation and periodical degradation from Cyclin-B during cell cycles development. Leptin inknown has role on oocyte maturation that works at mitogen activated protein kinase (MAPK). MAPK belongs to protein kinase family Ser/Thr that interact with MPF in arranging the progresivennes of oocyte meiosis through the help of c-mos. This interaction is initiated phosphorilation of Ser-369 and Thr-577 in p90rsk. Key words:leptin, MPF, and oocyte maturation.
Co-Authors Pieter Kakisina