Association between Resistin and High Sensitive Troponin I in St Elevation Myocardial Infarction and Systolic Heart Failure

Wasyanto, Trisulo
Febrilia, Laurent

Indonesian Journal of Medicine
Vol 5, No 1 (2020)

Background: Nearly half of all patients with acute myocardial infarction (AMI) have left ventri­cular systolic dysfunction and one-third have symptoms of heart failure (HF). In patients with AMI the resistin level correlated inversely with left ventricular ejection fraction (LVEF). Increased levels of high sensitive (hs) troponin I are associated with poorer prog­nosis. This study aimed to deter­mine the association between levels of resistin and hs troponin I in ST elevation myocardial infarc­tion (STEMI) patients with systolic HF.Subjects and Method: This was a cross-sectional study was conducted at Dr. Moewardi Gene­ral Hospital, Surakarta, from April 1 to May 31, 2018. A sample of 32 patients who admitted which diagnosed with STEMI was selected for this study. They were divided into two group according to result of LVEF mea­sure­ment, LVEF < 40% and LVEF ≥ 40%. Blood examination and transthoracic echo-car­diography were performed to all patients. Cor­re­lation test using partial and multiple cor­relation test. To different 2 mean using Mann Whitney test.Results: Mean of patient age was 59.5 years old. Resistin decreased LVEF (r= -0.41; p= 0.009), and it was statistically significant. Hs troponin I decreased LVEF (r= -0.25; p= 0.081), but it was marginally significant. Resis-tin level and hs troponin I increased LVEF (r= 0.47; p= 0.025), and it statistically significant.Conclusion: There was an association between resistin and hs troponin I level together in STEMI patients with systolic HF. There was an association of resistin levels in STEM I patients with systolic HF. There was no association of hs troponin I levels in STEMI patients with systolic HF.Keywords: Resistin, hs troponin I, STEMI, systolic heart failure.Correspondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hos-pital. Jl. Kol. Sutarto 132, Surakarta 57126, Central Java, Indonesia. Email: [e-mail] Journal of Medicine (2020), 5(1): 1-9https://doi.org/10.26911/theijmed.2020.05.01.01