Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase

Syaikhul Aziz (Program Studi Farmasi, Institut Teknologi Sumatera, Lampung Selatan, Indonesia, 35365)
Nur Adliani (Program Studi Farmasi, Institut Teknologi Sumatera, Lampung Selatan, Indonesia, 35365)
Sukrasno Sukrasno (Kelompok Keilmuan Biologi Farmasi, Sekolah Farmasi, Institut Teknologi Bandung, 40132, Indonesia)

Journal of Science and Applicative Technology
Vol 4 No 1 (2020): Journal of Science and Applicative Technology June Chapter

Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.