KARAKTERISASI NANOVESIKEL TRANSFERSOM SEBAGAI PEMBAWA “RUTIN” DALAM PENGEMBANGAN SEDIAAN TRANSDERMAL

Devi Ratnasari (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)
Effionora Anwar (Departemen Farmasetika, Fakultas Farmasi, Universitas Indonesia)

Jurnal Farmamedika (Pharmamedica Journal)
Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)

Transdermal become the alternative to deliver low solubility compound and low bioavalibility when given orally. Rutin is a flavonoid compound are found in watermelon and citrus. Rutin shows a low absorption when administered orally so the alternative is given in the transdermal route. A variety of approaches taken to increase the penetration of transdermal, one with nanovesikel carrier system. Transfersome is nanovesicle 200-300 nm sized composed of phospholipids, surfactants and water to increase penetration in trasndermal route. This study was to characterization transfersome containing rutin. The result show the size of transfersome < 150 nm, polydispersity index about 0.1 to 0.3, zeta potential less than -30 mV and entrapment efficiency > 80%.