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All Journal Jurnal Farmamedika (Pharmamedica Journal)
Effionora Anwar
Departemen Farmasetika, Fakultas Farmasi, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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KARAKTERISASI NANOVESIKEL TRANSFERSOM SEBAGAI PEMBAWA “RUTIN” DALAM PENGEMBANGAN SEDIAAN TRANSDERMAL Devi Ratnasari; Effionora Anwar
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (832.094 KB) | DOI: 10.47219/ath.v1i1.40

Abstract

Transdermal become the alternative to deliver low solubility compound and low bioavalibility when given orally. Rutin is a flavonoid compound are found in watermelon and citrus. Rutin shows a low absorption when administered orally so the alternative is given in the transdermal route. A variety of approaches taken to increase the penetration of transdermal, one with nanovesikel carrier system. Transfersome is nanovesicle 200-300 nm sized composed of phospholipids, surfactants and water to increase penetration in trasndermal route. This study was to characterization transfersome containing rutin. The result show the size of transfersome < 150 nm, polydispersity index about 0.1 to 0.3, zeta potential less than -30 mV and entrapment efficiency > 80%.
Co-Authors Devi Ratnasari