<![CDATA[Curcumin is one of secondary metabolites with phenolic group which was known tohave various biological activities such as antimicroba, anticancer, antioxidant, antitumorand anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4-piperidone derivative was synthesized using microwave irradiation with catalyst NaOH.The rendement (YN 2 ) resulted 99.39%. All compounds were characterized using UVspectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. Theantibacterial activity was evaluated using the agar diffusion method. Antibacterialactivity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc againstGram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gramnegative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compoundsobtained showed different antibacterial activity against different bacteria.]]>
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