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All Journal Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
A. Zamri
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Mathematics

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SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG 3’, 4’-DIMETOKSI KALKON Novianti, S.; Balatif, N.; Zamri, A.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcones belong to important class of flavonoid compounds. They have also beenreported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxicactivities. In this research, an analogous chalcone of (E)-3-(4-clorophenyl)-1-(3’,4’-dimetoxyphenyl) prop- 2-en-1-on was synthesized using microwave iradiation andnatrium hidroxide as catalyst. The compound showed a good yield, and then wascharacterized by UV spectroscopy, IR, 1 H-NMR, and Mass Spectroscopy. Its toxicityhas been identified using Brine Shrimp Lethality Test (BSLT) method on Artemiasalina Leach. The result showed that it had a good toxicity activity withLC 50 = 2.24 μg/ mL and potential as anticancer.
SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON ANALOG 2,5-DIMETOKSIBENZALDEHID Hidayat, T.; Zamri, A.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcones are a class of α,ß-unsaturated carbonyl compounds that forms the central coreof various naturally occurring biologically active compounds. They exhibit tremendouspotential to act as a pharmacological agent. It has been reported that they were active asantioxidant, antifungal, antibacterial, antidepressant, anticancer, anti-inflammatory andother biological activities. The chalcone analogue of 2,5-dimetoxibenzaldehyde ((E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on) was synthesized and tested forits toxicity using Brine Shrimp Lethality Test (BSLT) method. The purity of compoundhas been tested using TLC, melting point test, analytical HPLC. It was thencharacterized using UV, IR, 1 H-NMR and MS spectroscopy. LC 50 value of toxiccompound is <200μg/mL. Our result showed that (E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on compound was not potential as an anticancer since itsLC 50 was 1949 μg/mL.
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN) -1-METILPIPERIDIN-4-ON Hasanah, U.; Zamri, A.; Balatif, N.; Eryanti, Y.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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The derivatives of curcumin are secondary metabolites belonging to the phenolicgroup. Some of them were reported to have biological activities such as anti-inflammatory, anticancer and antioxidant activities. In this study, a curcumin of(3E,5E)-3,5-bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-onefrom1-methyl-4-piperidinone with 2-hydroxy benzaldehide has been successfully synthesized usingmicrowave irradiation method with NaOH (20%) as catalyst. Reaction was carried outfor 1 minute at 180 watt. The compound resulted was in the form of yellow crystalwith a yield of 72%. The compound was characterized by measuring its melting point,identifying by TLC, and elucidated by UV-Vis, FT-IR, MS, 1 H NMR, and 13 C NMR.Our result showed that the compound had the targeted molecule structure. Antibacterialtest was carried out using the agar diffusion method against Staphylococcus aureus,Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zoneranged from 6.5 to 10 mm and showed a very weak activity.
SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI Wahyuni, S.; Eryanti, Y.; Zamri, A.
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Curcumin is one of secondary metabolites with phenolic group which was known tohave various biological activities such as antimicroba, anticancer, antioxidant, antitumorand anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4-piperidone derivative was synthesized using microwave irradiation with catalyst NaOH.The rendement (YN 2 ) resulted 99.39%. All compounds were characterized using UVspectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. Theantibacterial activity was evaluated using the agar diffusion method. Antibacterialactivity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc againstGram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gramnegative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compoundsobtained showed different antibacterial activity against different bacteria.
Co-Authors N. Balatif S. Novianti S. Wahyuni T. Hidayat U. Hasanah Y. Eryanti