<![CDATA[Obesity is a complex disease characterized by fat accumulation in the body which led to increased risk ofother disease such as diabetic, cancer and others. Body mass index (BMI), is the main criteria to defineoverweight and obesity. In addition to the change in diet, exercise and life style, pharmacological optionswere used for complicated cases.This study is a retrospective one where the data collected were from 117 obese patients in obesity researchand therapy unit in AL-Kindy medical college in Iraq and were divided into four groups according to thedrugs that were taken (metformin group, metformin and orlistat group, metformin and fluoxetine group,metformin, orlistat and fluoxetine group)It has been found that each group showed a significant difference in BMI after 2 and four months andby comparison among the four group, metformin group was given a significant difference in BMI after 2months while no significant difference in BMI among groups after 4 months.In conclusion metformin alone gave the best change in BMI in short period with less side effect while forlong time, the administration of these three drugs together may lead to more desirable results]]>
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