Some Histogenetic Aspects of Methotrexate Associated with Juvenile Idiopathic Arthritis (JIA) Treatment Doses

Asal A. Tawfeeq1 , Sundus M. Taifoor2

Indian Journal of Forensic Medicine & Toxicology
Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

A total of (36) mice in the age of (1-3) weeks were selected to evaluate the methotrexate effect on somehistogenetic aspects of kidneys. Treatment lasted for three months, and results showed marked hemorrhage,cortical tubular basophilia, necroses, and degeneration in the autopsied organ of animals with low oralhydration. Besides, changes in the DNA methylation pattern were noticed in the RAPD-PCR profile uponanalysis with agarose gel electrophoresis.