The biologic behavior of the oral lesions can be determined by their active phases of cell division, cellsentering the cell cycle and their proliferation. AgNORs (argyrophilic nucleolar organizer regions) stainingis the one of the cytochemical technique used to evaluate the cell proliferation of oral lesions. Tumor cellsin premalignant and malignant conditions usually exhibits a rise in synthesis of abnormal proteins andproportionately there is a increase in the AgNOR material. The aim of this study was to review the conceptsof proliferative activity of cells of malignant and premalignant conditions through the AgNORs stainingprocedure and thereby proving the usefulness of AgNORs in diagnosing the oral lesions.
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