Indian Journal of Forensic Medicine & Toxicology
Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Synthesis and Biological Activities of New 1,2,3,4- Tetrahydroquinoline Derivatives Using Imino Diels-Alder Reaction

Mariam Abdul Jalil Abdul Razak1, Muhammad Abd Kadhum2 (Unknown)



Article Info

Publish Date
29 Oct 2020

Abstract

This research contains the preparation of some novel derivatives of tetrahydro quinolone. First step, includeprepared new Schiff’s bases compounds (I1-I5) were prepared by the direct condensation between diaminecompounds and aromatic aldehydes substituted by different groups. Tetrahydroquinoline derivativescompounds (I6-I10) were prepared through imino Diels-Alder reaction using the derivatives of Schiff basewith cinnamic acid, and Boron tri fluoride ethyl etherate (BF3.Et2O) as a catalyst. The prepared compoundswere identified by infrared spectra, 1H-NMR, and 13C-NMR. Antibacterial activity of the prepared compoundswas measured by using three pathogenic microorganisms including Staphyloccus haemolyticus, Klebsiellapneumonia,and Candida albicans. Also, a comparative study was achieved to study the biological activityof these prepared compounds using Agar Diffusion method.

Copyrights © 2020