<![CDATA[Serum FGF21 level is strongly associated with the onset of nephropathy in T2D patients and is an independentpredictor of loss of renal function in these patient.The study aimed to evaluate the role of FGF21 in earlydetection of diabetic nephropathy in type 2 diabetes patents. The study included Eighty-eight(88) samplesdivided in to four groups, three of which included type 2 diabetes patients, according to mircal test (urinealbumin / creatinine ratio), they were classified as :22normalbuminuria , 22 microalbuminuria, and 22macroalbuminuria. The fourth group included 22 apparently healthy subjects with (matched gender andage).The mean ±SD of serum fibroblast growth factor 21 of normoalbuminuria group was (225.00±38.62),microalbuminuria group was (267.78±51.08) and macroalbuminuria group was (230.84±50.33) .Thecomparison results indicated significant increase (p?0.05) of FGF21 in microalbuminuria group in comparisonto that level in normoalbuminurea and macroalbuminuria groups. Also highly significant increase of FGF21was observed in microalbuminuria group in comparison to that level in control group. We conclude thatFGF21 may be a useful marker for early detection of nephropathy]]>
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