<![CDATA[The purpose of this study is to explain the effect of a low-carbohydrate-high-protein (LCHP) diet onreducing TNF-? levels. The study was carried out with true experimental post-test only control design, using3-month-old females rats (Rattus norvegicus) with a bodyweight of 200-300 g, which were divided intothree groups: Negative control (K-) (rats without treatment were fed with broiler standard feed), Positivecontrol (K+) (PCOS-IR model rats were fed broiler standard feed), and Treatment (P) (PCOS-IR modelmice were fed with LCHP diet). Serum taken from the rats’ heart on day 49 was examined for TNF-? levelsusing Bioassay Germany ELISA kit. Statistical analysis was carried out using ANOVA and Post Hoc tests.ANOVA analysis of TNF-? resulted in a p value of 0.0017, indicating significant difference of TNF-? levelswhen LCHP diet was applied, followed by Post Hoc test found that the TNF-? level of the treatment group(p = 0.006) is lower than the positive control group (p = 0.038). One of the roles of a low-carbohydrate dietin the pathogenesis of PCOS-IR is to provide an inflammatory repair effect by increasing insulin sensitivity,improving insulin levels, and stimulating an increase in steroidogenesis synthesis. Increased breakdown offatty acids is inhibited, so that it does not cause a build-up of fatty acids and does not induce an increasein proinflammatory cytokines against gonadotropins, increasing FSH secretion and effecting folliculardevelopment.]]>
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