<![CDATA[P38 mitogen-activated protein kinase (p38MAPK) is the activity of the p38MAPK pathway in muscle cellscausing mitogen-activated disorders that are responsive to stress stimuli, such as cytokines, and involvedin cell differentiation, and apoptosis. Characteristic of p38MAPK expression contributes to metabolicsignal on the reduction and excessive production of ovarian androgen found among women with endocrineand metabolic disorders. We suspect that p38MAPK expression changes in ovarian granulosa cells. Thisresearch aims to observe changes in p38MAPK expression among PCOS-RI mice fed by a low-protein,high-carbohydrate (RKTP) diet. Testosterone propionate was given to induce the PCOS-IR model, 0.1ml injection of for 28 days intramuscularly on 18 mice. Each mouse was examined for vaginal swabsand ovarian histology. At the end of treatment, the p38MAPK expression score kept increasing and had asignificant negative effect with ANOVA test p value = 0.149 (p >0.05). The results of the treatment groupposttest showed p38MAPK expression, and there was a decrease compared to the control group. Theseoccurred because the RKTP diet has not been able to stimulate RE stress through the NFK? pathway, sothe NFK? pathway increased AGEs receptors on granulosa cells that played a role in oocyte maturation asa response in the follicular development process on PCOS-IR model. Moreover, in this research RKTP diethad not been able to reduce p38MAPK expression in granulosa cells in the ovary]]>
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