<![CDATA[Objective :To explain a important of Forkhead box O3(FoxO3 ) protein level in progression of Nodalosteoarthritis (NOA) disease , the location of study at fallujah – Iraq at February 2020 .Method: Collection of samples take for patients with NOA and controls at Rheumatology & RehabilitationConsultation Unit in Al-fallujah Teaching Hospital / Iraq .The Diagnosis NOA patients depended onAmerican College of Rheumatology (ACR) criteria and used technique of ELISA to measure FoxO3 proteinlevel.Results: This study show NOA patient grade 1 have non significant decrease when compare with controlgroup in FoxO3 protein level ,but observed significant decrease when compare with NOA patient grade 4.Also show significant decrease when compare NOA patient grade 4 with control group .Conclusion: This study show that level of FoxO3 protein decrease in NOA cartilage, this lead to reduce ofautophayg and antioxidant proteins .This decrease can result progression of NOA disease .]]>
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