<![CDATA[Matrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolyticenzymes that are known to play a key role in the catabolic turnover of extracellular matrix (ECM)components. Research studies to date have indicated that MMPs regulate the activity of several non-ECMbioactive substrates, including growth factor, cytokines, chemokines and cell receptors which determine thetissue microenvironment. Disruption of the balance between the concentration of active metalloproteinasesand their inhibitors (TIMPS) may lead to pathological changes associated with uncontrolled ECM turnover,tissue remodeling, inflammatory response, cell growth and migration. This brief review presents someinformation on MMPs role in inflammatory, metabolic and cancer abnormalities related to the salivaryglands, as well as MMP- related aspects that lead to the formation of human dentinal caries lesions. In oraldiseases, the most relevant biological fluid commonly used for diagnosing periodontal diseases in saliva.Conventional treatment successfully reduces the levels of MMPs inhibits the progressive breakdown ofgingival and periodontal ligament collagens.]]>
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