Indian Journal of Forensic Medicine & Toxicology
Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Matrix Metalloproteinases (MMPS) and its Role in Cancers - A Review

J. Aparna1 , M.P. Brundha2 (Unknown)



Article Info

Publish Date
29 Oct 2020

Abstract

The main aim of this study is to analyze the role of Matrix metalloproteinases genes in cancer progressionand metastasis. Matrix metalloproteinase genes were identified in humans, and many are involved in cancer.Extracellular matrix (ECM) degradation by matrix metalloproteinase not only enhances tumour invasionbut also affects tumour cell behaviour and leads to cancer progression. This review highlights recentdevelopments in the cellular and molecular mechanisms of matrix metalloproteinase that influence tumourcell growth, invasion, and metastasis. A review with recent information about matrix metalloproteinases andits role in cancer collected from search engines from the articles dated from 2000-2020. The recent articlesdiscussed in this review help to gain knowledge and understanding of Matrix metalloproteinases in cancerinvasion and progression, metastasis, angiogenesis, and aid in the analysis of the mutations caused whichaid the medical field to prevent tumour progression.

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