This study aims to realization the conceivable therapeutic of melatonin effects experimental againstEnterobius vermicularis in rats. Implement this experiment during the period from August 2019 to January2020. E.vermicularis infected with male wistar rats orally with dose 15mg/kg melatonin former of bodyweight for 30 day showed significantly reduction in the number of eggs and worms compared with ratsorally with dose 15mg/kg melatonin accompanying and untreated rats for 30 day (P < 0.05).Histologically inintestine examined show increase numbers of leucocytes produce, necrosis significant scatter and reductionthis parasite of tissue in rats treated with melatonin. This results show influence of melatonin in the controlon Enterobiosis and suggestion that this drug usefulness in Enterobius vermicularis infection therapy
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