Jurnal Farmasi Sains dan Komunitas
Vol 9, No 2 (2012)

OPTIMASI FORMULA TABLET EFFERVESCENT EKSTRAK RIMPANG JAHE MERAH (Zingiber officinale Roxb. Var rubrum)

Henny Dwi Arini (Unika Widya Mandala, Surabaya)
Lannie Hadisoewignyo (Unika Widya Mandala, Surabaya)



Article Info

Publish Date
01 Nov 2012

Abstract

Abstract:This study aims to determine the effect of sodium citrate and fumaric acid as a source ofacid in the tablet formula effervescent red ginger rhizome extract (Zingiber officinale Roxb. varrubrum) and obtain the optimum composition of the formula that has the physical properties oftablet effervescent red ginger rhizome extract (Zingiber officinale Roxb. var rubrum) that meetthe requirements. Optimization techniques used in research is a method of factorial design withtwo factors and two levels of sodium citrate and fumaric acid with low levels of 80 mg, and highlevels of 120 mg. Responses were observed to obtain optimum formula is hardness, friability, andthe soluble tablet (effervescent time). The result is the concentration of sodium citrate andfumaric acid did not significantly affect tablet hardness effervescent. Meanwhile, that issignificantly influences the friability and time effervescent soluble tablets. However, theinteraction between sodium citrate and fumaric acid did not significantly affect the hardness,friability, and the soluble tablet effervescent red giinger extract. Optimum formula tabletsobtained effervescent namely sodium citrate 80 mg and 80 mg of fumaric acid with 6,529 kgfresponse tablet hardness, tablet friability 0,1354%, and effervescent time of 5,98 minutes.Key words : Red ginger, effervescent tablet, factorial design

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Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...