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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JFIOnline Jurnal Masyarakat Madani Indonesia Widya Teknik Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Lannie Hadisoewignyo
Faculty Of Pharmacy, Widya Mandala Catholic University Surabaya, Jalan Raya Kalisari Selatan No. 1, Pakuwon City, Surabaya, Indonesia, 60112
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Effect of Various Concentration of Vegetable Protein in Hair Mask on The Hair Texture Helen, Ivony; Hadinoto, Idajani; Hadisoewignyo, Lannie; Soegianto, Lisa
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Effect of various concentrations of vegetable protein in hair mask on the hair texture including hair smoothness, hair shining, hair strength, and morphology of hair had been studied. Concentrations of vegetable protein are made 5%, 7.5%, and 10%. The hair mask was evaluated such as organoleptic, pH, viscosity, and allergy test. Hair mask used in six subjects that have damage hair for 8 times every 2 days. Then, the hair mask was evaluated such as hair smooth and hair shine that used tree trained panel and analyzed using non parametric method Q Cochran. Hair strength was evaluated using autograph  then  the  results  were    analyzes  using  ANOVA  test  (p<0.05),  while  hair morphology  was  evaluated  using  scanning  microscope  electron  (SEM).  The experimental  results  showed  that  vegetable  protein  in  hair  mask  increased  hair smoothness, hair strength, and morphology of damaged hair but did not give effect for hair shining. Various concentrations of vegetable protein (5%, 7.5%, and 10%) on hair mask given the same effect in hair texture (hair smoothness, hair strength, and hair morphology).
Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.107 KB) | DOI: 10.14499/indonesianjpharm0iss0pp133-140

Abstract

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.
Efek Fraksi Air Daun Salam (Syzygium polyanthum) Terhadap Imunitas Alami Tikus Wistar Jantan Tamayanti, Wahyu Dewi; Soegianto, Lisa; Nurak, Elisabeth; Hadisoewignyo, Lannie; Ervina, Martha
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4023.955 KB) | DOI: 10.33508/jfst.v2i1.702

Abstract

Pemberian fraksi air daun salam (Syzygium polyanthum) terhadap jumlah netrofil dan kadar IL-6 tjkus Wistarjantan yang telah diinduksi Staphylococcus aureus telah dilakukan. Tikus Wistar jantan dibagi dalam 3 ckelompok, masing-masing terdiri dari 5 ekor tikus, yaitu kelompok kontrol negatif (perlakuan NaCI 0,9%) kelompok uji (perlakuan fraksi air daun salam 200 mg/kg BB) dan ~elompok kontrol positif (perlakuan suspensi ibuprofen 400 mg/kg BB). Tikus dengan perlakuan dikorbankan satu jam setelah induksi Staphylococcus aureus, dan diambil darahnya. Perhitungan jumlah netrofil darah dilakukan .di bawah mikroskop dan penentuan kadar IL-6 dilakukan dengan metode ELISA. Hasil ana lisa data dengan anava satu arah mengindikasikan bahwa daun salam tidak menurunkan jumlah netrofil darah maupun IL-6 pada tikus Wistar jantan yang terinduksi Staphylococcus aureus.
Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats Hadisoewignyo, Lannie; Soeliono, Ivonne; Hartono, Sandy Budi; Hestianah, Eka Pramhyrta; Mahanani, Sri Rahayu
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.217 KB) | DOI: 10.14499/indonesianjpharm30iss2pp114-121

Abstract

It has been reported that curcumin has a hepatoprotective effect, but its low solubility limited its utilization. Recently there was so many emerging research of advanced curcumin formulation, such as nanoparticles curcumin. In our previous study, curcumin has been loaded into mesoporous silica nanoparticles (C-MSN). This study was performed both to evaluate of C-MSN hepatoprotective effect in CCl4-induced rats. Sixteen rats were divided into four groups, namely normal and CCl4 control, curcumin, C-MSN group. Treatment was given according to its group for fourteen days consecutively. At day 14, three hours after the last administration, CCl4 (1,25 ml/kgBB) were administered orally. Twelve hours later the rats were sacrificed, and blood samples were drawn from their hearts. Blood serum examination result revealed that C-MSN caused a significantly lower ALT and AST than CCl4 control group (851±271 U/L vs 1734±275 U/L; 295±155 U/L vs 1348±235 U/L; p<0.05). Its effect on hepatic serum level resembled curcumin group. However, the result was not supported by histology examination which showed a higher number of necrotic hepatic cells in C-MSN group than in the curcumin group (147±9 vs 80±16; p<0.05). From this study, it can be concluded that C-MSN revealed an excellent hepatoprotective property, but it was suspected that MSN itself has the toxic effect on the liver. A further study of MSN toxicity was needed to support its safety use. 
OPTIMASI FORMULA TABLET LEPAS LAMBAT IBUPROFEN Sumargo, Fredy; Hadisoewignyo, Lannie
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.56

Abstract

Ibuprofen was one type of antiinflammation drug that is often used so frequently in a day. Therefore, ibuprofen should be formulated in the form of sustained release tablet and find the optimum formula using factorial design. Factors used are a concentration of combination locust bean gum â?? xanthan gum matrix at 5% - 10% and concentration PVP K-30 at 3% - 5%. Preferred response Banakar follow the criteria was percent of dissolved drug in 3 hours at 25% - 50% and the percent of dissolved drug in 6 hours at 45% - 75%. The purpose of this study was to determine the effect of both factors and their interactions and get the optimum formula for the disposal of the following criteria Banakar. Concentration of combination xanthan gum-locust bean gum and concentration of PVP K-30 factor inhibit dissolved ibuprofen from tablets. While their interaction increase dissolved ibuprofen from tablet. Based on Design-Expert program optimation, optimum formula was obtained using a concentration of combination locust bean gum â?? xanthan gum matrix 7.58% and concentration of PVP K-30 3.09% would be result dissolved drug in 3 hours amounted to 49.3137% and dissolved drug in 6 hours amounted to 51.7607%.   ABSTRAK Ibuprofen merupakan obat  antiinflamasi yang digunakan dengan frekuensi penggunaan berulang kali dalam sehari. Oleh karena itu, ibuprofen perlu diformulasikan dalam bentuk lepas lambat dan dicari formula optimumnya dengan menggunakan metode factorial design. Faktor yang digunakan adalah faktor konsentrasi kombinasi matriks locust bean gum â?? xanthan gum pada konsentrasi 5% â?? 10% dan faktor konsentrasi PVP K-30 pada konsentrasi 3% - 5%. Respon yang dipilih mengikuti kriteria Banakar yaitu persen obat larut 3 jam 25 â?? 50% dan persen obat larut 6 jam 45 â?? 75%. Tujuan penelitian ini adalah mengetahui pengaruh kedua faktor dan interaksinya serta untuk memperoleh formula optimum yang pelepasannya mengikuti kriteria Banakar. Faktor konsentrasi kombinasi matriks locust bean gum â?? xanthan gum dan faktor konsentrasi PVP K-30 menghambat jumlah ibuprofen yang larut. Interaksi kedua faktor meningkatkan jumlah ibuprofen yang larut. Berdasarkan program optimasi Design Expert diperoleh formula optimum menggunakan konsentrasi kombinasi matriks xanthan gum-locust bean gum 7,5775% dan konsentrasi PVP K-30 3,09%,menghasilkan persen obat terlepas 3 jam sebesar 49,3137% dan persen obat terlepas 6 jam sebesar 51,7607%.
Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum Elim, Siska; Hadisoewignyo, Lannie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (800.677 KB) | DOI: 10.33508/jfst.v1i1.2345

Abstract

Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.
Optimization of formula sustained releaase captopril tablet using factorial design method Pratiwi, Melinda; Hadisoewignyo, Lannie
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.845 KB) | DOI: 10.14499/indonesianjpharm0iss0pp272-282

Abstract

Captopril is one of the most frequently used  medicine  in the treatment of hypertension  with  repeatedly  used  frequency  in  a  day.  Therefore  captopril should  be  formulated  in  the  form  of  sustained  release  and  find  the  optimum formula.  The  purpose  of  this  study  was  to  determine  the  influence  of  both factors  and  their  interactions,  which  are  the  ratio  of  polymer  HPMC  K4M  -xanthan gum  factor at the level of 1:1 and 4:1 and the concentration of tartaric acid  at  levels  of  0%  and  5%  on  physical  properties  of  tablets,  drug  release, floating  lag  time.  Furthermore,  find  the  optimum  formula  that  meets  the requirements  and  produce  tablets  with  drug  release  pattern  according  to  zero order  kinetics.  Based  on  Design  Expert  optimization  program  was  obtained  the optimum  formula  using  a  combination  of  polymer  HPMC  K4M  –  xanthan  gum ratio  3.75:1  and  concentration  of  of  tartaric  acid  4.5%  would  be  result  the hardness  respons  12.02  Kp  the  friability  0.47%,  the  floating  lag  time  0.32 minutes,  and  the  rate  of  dissolution  0.05  mg/min.  The  results  show  that combination of factors polymer HPMC K4M -  xanthan gum ratio can increase the tablet  hardness,  lower  tablet  friability,  accelerate  the  floating  lag  time,  and increase the rate  of dissolution.  Tartaric acid can  decrease  the  tablet  hardness, increase  the  friability,  accelerate  the  floating  lag  time,  and  increase   the  rate  of dissolution.  Interaction  of  both  can  reduce  the  tablet  hardness,  increase  the tablet friability, slow floating lag time, and increase the rate of dissolution.Key words: captopril, HPMC K4M, xanthan gum, tartaric acid, factorial design
Ibuprofen salt production and its application in tablet dosage form Hadisoewignyo, Lannie; Fudholi, Achmad; Muchalal, M.
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.59 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-150

Abstract

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
Influence of filler-binders on ibuprofen iablets with direct compression method Hadisoewignyo, Lannie; Teny, Gracesya Florensya; Handayani, Elok Tri; Yunita, Beby
Indonesian Journal of Pharmacy Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.932 KB) | DOI: 10.14499/indonesianjpharm0iss0pp279-285

Abstract

Ibuprofen  is  a  active  ingredient  that  have  low  melting  point,  but  it  has poor  flowability,  and  poor  compactibility,  this  causes  ibuprofen  tablets  are  not suitable  to  be  made  by   direct  compression  method.   The  use  of  appropiate filler-binders  can  improved  the  flow  properties  and  compactibility  powder  that can be made  by  direct compression. Filler binders  commonly use  are  Avicel PH 102, Emcompress, SDl, and Starch 1500. Formula tablet ibruprofen using Avicel PH 102 as filler-binder will produce tablet with good hardness, low friability, fast disintegrating,  and  high  dissolution.  This  is  because  the  hydrophilic  properties and plastic deformation which is owned by Avicel PH 102.Key words:Ibuprofen, Avicel PH 102, direct compression
OPTIMASI FORMULA TABLET EFFERVESCENT EKSTRAK RIMPANG JAHE MERAH (Zingiber officinale Roxb. Var rubrum) Henny Dwi Arini; Lannie Hadisoewignyo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (700.558 KB) | DOI: 10.24071/jpsc.0074

Abstract

Abstract:This study aims to determine the effect of sodium citrate and fumaric acid as a source ofacid in the tablet formula effervescent red ginger rhizome extract (Zingiber officinale Roxb. varrubrum) and obtain the optimum composition of the formula that has the physical properties oftablet effervescent red ginger rhizome extract (Zingiber officinale Roxb. var rubrum) that meetthe requirements. Optimization techniques used in research is a method of factorial design withtwo factors and two levels of sodium citrate and fumaric acid with low levels of 80 mg, and highlevels of 120 mg. Responses were observed to obtain optimum formula is hardness, friability, andthe soluble tablet (effervescent time). The result is the concentration of sodium citrate andfumaric acid did not significantly affect tablet hardness effervescent. Meanwhile, that issignificantly influences the friability and time effervescent soluble tablets. However, theinteraction between sodium citrate and fumaric acid did not significantly affect the hardness,friability, and the soluble tablet effervescent red giinger extract. Optimum formula tabletsobtained effervescent namely sodium citrate 80 mg and 80 mg of fumaric acid with 6,529 kgfresponse tablet hardness, tablet friability 0,1354%, and effervescent time of 5,98 minutes.Key words : Red ginger, effervescent tablet, factorial design
Co-Authors . Antaresti Achmad Fudholi Elim, Siska Emi Sukarti, Emi Evania hadi Farida Lanawati Darsono Fudholi, Achmad Handayani, Elok Tri Hartono, Sandy Budi Henny Dwi Arini Hestianah, Eka Pramhyrta Idajani Hadinoto Idajani Hadinoto Ivonne Soeliono Ivony Helen Ivony Helen Lisa Soegianto Lisa Soegianto Lucia Hendriati Mahanani, Sri Rahayu Martha Ervina Muchalal, M. Nehru Wibowo Nurak, Elisabeth Prasetyo, Jefri Pratiwi, Melinda Sandy Budi Hartono Sinansari, Restry Sumargo, Fredy Teguh Widodo Teny, Gracesya Florensya Wahyu Dewi Tamayanti, Wahyu Dewi Wuryanto Hadinugroho Yunita, Beby