Jurnal Farmasi Sains dan Komunitas
Vol 13, No 2 (2016)

STABILITAS EPIGALOKATEKIN GALAT DALAM KRIM EKSTRAK TEH HIJAU DENGAN VARIASI KONSENTRASI ANTIOKSIDAN VITAMIN C 1% DAN VITAMIN E 1%

Nining Sugihartini (Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia)
Hari Susanti (Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia)
Zaenab Zaenab (Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia)
Hana Hanifah (Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia)
Siti Ayu Marlina (Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia)



Article Info

Publish Date
04 Nov 2016

Abstract

Epigallocatechingallate (EGCG) in green tea extract has activity as an anti-inflammatory agent. On the other hand the stability of EGCG is poor because of the oxidation. The aim of this study was to determine the influence of Vitamine C and Vitamine E in formulation of green tea extract cream to the stabiliy of EGCG. The green tea extract was obtained from the extraction process by infundation followed by fractination with ethyl acetate as the solvent. The three formulas were compiled in similar composition with the concentration of vitamine C 1% (FI), Vitamine E 1% (FII) and there was no Vitamine C and Vitamine E (FIII) as a control. The EGCG level was determinated by TLC-densitometry methode. The stability parameter was determinated by calculated of the Q10 of each formula. The result of this study showed that the parameter of t90 of EGCG with Vitamine C 1%, Vitamine E 1% and control addition were 0.0108 hours, 0.0087 hours, 0.0084 hours, respectively. Stability of EGCG in green tea leaf extract cream with addition of the vitamin C 1% was higher than it stability with the addition of vitamin E 1%. The concentration of Vitamin C 1% was the optimum concentration as antioxidant in formulation of green tea extract cream.

Copyrights © 2016






Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...