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VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KLT DENSITOMETRI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, .
PHARMACIANA Vol 2, No 1: Mei 2012
Publisher : PHARMACIANA

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Abstract

KLT Densitometri adalah salah satu metode yang banyak digunakan untuk penetapan kadar bahan aktif. Salah satu bahan aktif tersebut adalah epigalokatekin galat dalam ekstrak teh hijau yang banyak digunakan dalam produk krim. Metode tersebut perlu divalidasi untuk membuktikan hasil pengukuran mendekati kadar yang sesungguhnya. Tujuan penelitian ini ingin membuktikan bahwa metode KLT Densitometri yang digunakan akan memberikan linieritas, ketelitian, ketepatan yang memenuhi persyaratan serta mengetahui nilai LOD(Limit if Detection) dan LOQ (Limit of Quantitation). Penelitian menggunakan kadar 600, 1800 dan 3000 ?g dengan replikasi 3 kali untuk mengetahui ketelitian (berdasarkan nilai CV) dan ketepatan (berdasarkan nilai perolehan kembali). Linieritas diketahui dengan menghitung nilai r pada kurva hubungan antara kadar dan luas area kromatogram yang selanjutnya persamaan kurva baku digunakan untuk menghitung LOD dan LOQ. Hasil penelitian menunjukkan bahwa metode yang digunakan memenuhi persyaratan liniearitas dengan nilai r=0,98. Nilai CV untuk kadar 600, 1800 dan 3000 ug masing-masing 8,18%; 3,19% dan 1,53% dan perolehan kembali masing-masing 88,10%; 99,65% dan 111,33%. Nilai LOD adalah 827,01 ?g/ml dan LOQ adalah 2756,69 ?g/ml.
OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Sugihartini, Nining
PHARMACIANA Vol 1, No 2: November 2011
Publisher : PHARMACIANA

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Abstract

Oktil metoksisinamat (OMS) merupakan bahan aktif tabir surya yang akan mengalami degradasi setelah mendapat paparan sinar matahari. Di lain pihak, antioksidan memiliki potensi sebagai fotoprotektor sehingga dalam penelitian ini digunakan fraksi etanol daun Plantago major, L untuk mendukung potensi OMS. Selain itu ditambahkan juga tepung beras karena memiliki kemampuan untuk memantulkan cahaya matahari. Penelitian ini bertujuan untuk mendapatkan komposisi optimum keduanya berdasarkan efektifitas OMS. Pada penelitian ini digunakan tiga formula berdasarkan metode simplex lattice design dengan perbandingan fraksi etanol daun Plantago major, L dan tepung beras sbb: FI (100%:0%), formula II (50%:50%), formula III (0%:100%). Ketiga formula dipaparkan cahaya matahari selama 5 jam (pukul 09.00-14.00 WIB) dengan setiap interval satu jam sampel diambil untuk ditetapkan nilai % transmisi eritema (%Te) dan pigmentasi (%Tp). Data yang diperoleh kemudian dianalisis untuk ditetapkan komposisi optimum yaitu yang memberikan nilai respon tertinggi. Hasil penelitian menunjukkan bahwa penambahan 100% tepung beras merupakan penambahan yang paling optimum untuk mendukung aktivitas OMS sebagai tabir surya dengan penurunan % transmsisi eritema sebesar 200% dan pigmentasi sebesar 75%.
OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (D.C) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN Nurlaela, Endah; Sugihartini, Nining; Ikhsanudin, Azis
PHARMACIANA Vol 2, No 1: Mei 2012
Publisher : PHARMACIANA

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Abstract

Penyakit demam berdarah dengue (DBD) merupakan penyakit yang disebabkan oleh gigitan nyamuk Aedes aegypti betina. Krim repelan minyak atsiri daun sere dapat digunakan untuk mencegah gigitan nyamuk tersebut. Dalam krim minyak atsiri sere (Cymbopogon citratus (D.C) Stapf) diperlukan emulgator untuk menjaga stabilitas krim. Tween 80 dan Span 80 merupakan emulgator yang banyak dipergunakan dalam formula krim. Penelitian ini bertujuan untuk mengetahui komposisi optimum Tween 80 dan Span 80 yang digunakan sebagai emulgator dalam krim repelan minyak atsiri daun sere pada basis Vanishing Cream dengan menggunakan metode Simplex Lattice Design. Tiga Formula krim dirancang berdasarkan metode Simplex Lattice Design dengan perbandingan Tween 80:Span 80 sbb: F I (100%-0%), F II (50% - 50%), F III (0% - 100%). Krim yang diperoleh kemudian diuji aktifitas repelan dan sifat fisik yang meliputi uji daya sebar, uji daya lekat dan uji iritasi. Hasil uji sifat fisik dan aktifitas repelan dibuat profil dan dihitung respon total untuk mendapatkan formula optimum. Validitas metode optimasi dilakukan dengan membandingkan hasil percobaan dengan hasil prediksi pada krim formula optimum dengan uji t pada taraf kepercayan 95%. Hasil yang diperoleh menunjukkan bahwa komposisi optimum diperoleh pada komposisi Tween 80: Span 80 sebesar 60%:40% . Krim dengan komposisi optimum emulgator diprediksi memiliki daya sebar 29,24 cm2; daya lekat 3,512 detik; iritasi 0,608; daya repelan 41,469 menit. Hasil uji t menunjukkan perbedaan yang tidak signifikan antara hasil percobaan dengan hasil prediksi (p<0,05).
Curcumin and Extract of Plantago major, L Increased SPF Value of Cold Cream Base Sugihartini, Nining
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Research Gateway

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Abstract

Octyl methoxycinnamate as the active material of the sunscreen would be degradated after being exposed to the sunlight. Curcumin, rice flour and the  extract of  Plantago  major, L was the material that could function as the sunscreen. The aim of this research was to know the SPF value and the physical characteristics of cream of  the sunscreen with the active material octyl methoxycinnamate after the addition of the optimum composition of curcumin and the extract of Plantago major, L and the optimum composition of rice flour and the extract of Plantago major, L. In this research three formulas was examined, i.e. the  formula I with the active material octyl methoxycinnamate, the formula II with the active material octyl methoxycinnamate  and the optimum composition curcumin and the extract of  Plantago  major, L, Formula III with the active material octyl methoxycinnamate and the optimum composition rice flour and the extract of Plantago major, L. SPF value of each formula was determined by using the Petro method (1981) using UV spectrofotometric method at a  λ 290 nm-320 nm. The physical characteristics i.e. the power spread, the adhesiveness and the viscosity were also examined analysed with Anova one way at a confidence level  95%. Result of the research show that SPF value increased after the addition of the optimum composition of curcumin and the extract of Plantago major, L. The physical characteristics of cream of the sunscreen do not change after the addition of the optimum composition curcumin and the extract of  Plantago major, L and the optimum composition rice flour and the extract of Plantago major, L. 
VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.727 KB) | DOI: 10.12928/pharmaciana.v4i1.396

Abstract

High Performance Liquid Chromatography (HPLC) was one of analytical methods commonlyto determine the concentration of epigallocatechin gallate (EGCG) on green tea extract. The methodmust be validated in order to fit to its purpose. The aim of this research was to prove that the usedmethod has selectifity, liniearity, precise, accurate and know limit of detection (LOD) and limit ofquantification (LOQ) is acceptable. The selectifity of analytical method was determined bycalculating the resolution value between two peak. Data from 10 ug/ml and 100 ug/ml with 5replicates would give precition and accuration. Precition was known from CV value and accurationwas known from recovery value in each concentration. Liniearity was known from regression linearbetween concentration and wide area of peak. From regresion linear could calculate LOD and LOQ.Research show that method of analyse have selectificity with Rs= 2,27>1,5; liniearity with r= 0,99;precision with CV 8,74% at concentration 200 µg/ml and 3,74% at concentration 500 µg/ml;accuration with recovery 99,76% at concentration 200 µg/ml and 100,52% at concentration 500 µg/mland the value of LOD is 33,28 ug/ml and LOQ is 110,93 ug/ml.
FORMULASI GEL EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DENGAN VARIASI GELLING AGENT SEBAGAI SEDIAAN LUKA BAKAR Maulina, Lena; Sugihartini, Nining
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.163 KB) | DOI: 10.12928/pharmaciana.v5i1.2285

Abstract

Pericarp of mangosteen is waste that has been shown have efficacy as an anti-inflammatory and accelerate the proliferation of fibroblasts. Therefore  it need to be formulated in the form of gel to make easy in the use of preparation. It is needed an appropriate gelling agent to produce the good character of gel. This research aimed to know the type of the gelling agent who has the physical properties gel and the activity of the best treat burns. There are three gel formula designed with various  type of  the gelling agent i.e. FI (the gelling agent carbopol); FII (the gelling agent CMC na); FIII (the gelling agent tragacanth). The obtained gels were tested organoleptic, of homogeneity, pH, spreadibility, adhesivity, consistency and the effect of healing burns in nine groups. The collected data were analyzed statistically using SPSS version 16 with kolmogorov-smirnov and continued one way ANOVA or  Kruskal-Wallis, with level of trust 95 %. The results show that all formula mixed homogeneous gel. Formula I have a pH 3,5 while formula II and III having a ph 5 (p < 0,05). The greater spreadibility given by formula III (p < 0,05) and the longest time of adhesivity given by formula II (p < 0,05). The best activity of wound healing given by formula I (p > 0,05). Based on the result show that type of gelling agent can influence the physical properties and activity in the treating burns. Type of gelling agent that show the best physical properties is CMC Na.
OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Sugihartini, Nining
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.4 KB) | DOI: 10.12928/pharmaciana.v1i2.525

Abstract

Octyl methoxycinnamate is an active ingredient in sunscreen that will bedegradated after exposure by sunlight. On the other hand, antioxidants have potentialcapability as photoprotector which in this study is used the ethanol fraction of leaf ofPlantago major, L to support activity of OMS. In addition, rice flour is added toobecause it has the ability to reflect sunlight. The aim of this study is to obtain theoptimum composition of them, based on the effectivity of OMS. This study used threeformulas based on the simplex lattice design method with a comparison of octylmethoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%:50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the valueof % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed toget the optimum composition which has the highest of response. The results showed that100% rice flour was the optimum addition to support activity of OMS as sunscreen withdecreasing of % erythema transmission and pigmentation was 200%, 75%,respectively.
VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KLT DENSITOMETRI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (81.542 KB) | DOI: 10.12928/pharmaciana.v2i1.656

Abstract

TLC Densitometry is one of method which was used to measure amount of activesubstance. Active substance of epigallocathechin gallate is one of in green tea extractcream. Method of analysis must be validated to prove that method will give the dataclose with the real value. Aim of this research is to prove that TLC Densitometry methodhave liniearity, precision and accuration that fulfill the requirement. This study usedconcentration 600, 1800 and 3000 ug/ml with 3 replications to measure precision(based on value of CV) and accuration (based on value of recovery). Liniearity wasknown based on value of r of curve regression between concentration and wide area ofchromatogram. LOD and LOQ was calculated based on curve regression. Researchshowed that method of analyse had liniearity with r= 0,98. Value of CV concentrationof 600, 1800 and 3000 ug/ml were 8,18%; 3,19% and 1,53%, respectively and recoverywere 88,10%; 99,65% dan 111,33%, respectively. Value of LOD was 827,01 µg/ml andLOQ was 2756,69 µg/ml.
OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (DC) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN Nurlaela, Endah; Sugihartini, Nining; Ikhsanudin, Azis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (106.202 KB) | DOI: 10.12928/pharmaciana.v2i1.652

Abstract

The disease of Dengue hemorrhagic fever (DHF) is caused by the bite of femaleAedes aegypti mosquito. Cream of repelan sere leaf essential oils can be used to preventmosquito bites. The cream of volatile oil sere (Cymbopogon citratus (DC) Stapf)required emulsifier to maintain the stability of cream. Tween 80 and Span 80 is a widelyused emulsifier in a cream formula. Aims of this study is to determine the optimumcomposition of Tween 80 and Span 80 as emulsifier in a cream repelan of sere leafessential oils in the basis Vanishing Cream with Simplex Lattice Design methode. ThreeFormula cream is designed based on the Simplex Lattice Design methode with a ratio ofTween 80: Span 80 as follows: FI (100%-0%), F II (50%-50%), F III (0%-100%).Cream was then tested repelan activity and physical properties that includespreadibility, adhesivity and irritation. Data of physical properties and repellantactivity was calculate to get the optimum formula. The validity of optimization methodswas evaluated by comparing experimental results with predicted results in optimumcream formula with t test at 95% level of confidence. The results of study showed that theoptimum composition of Tween 80: Span 80 was 60%:40%. Cream with optimumemulsifier composition was predicted has spreadibility 29.24 cm2; adhesivity 3.512seconds; irritation 0.608; power repelan 41.469 minutes. T test results showed nosignificant differences between the experimental results and predicted results (p<0.05).
VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.743 KB) | DOI: 10.12928/pharmaciana.v4i2.1567

Abstract

High Performance Liquid Chromatography (HPLC) was one of analytical methodscommonly used to determine the concentration of epigallocatechin gallate (EGCG) on green teaextract. The method must be validated in order to fit to its purpose. The aim of this research was toprove that the used method has selectifity, liniearity, precise, accurate and know limit of detection(LOD) and limit of quantification (LOQ) is acceptable. The selectivity of analytical method wasdetermined by calculating the resolution value between two peak. Data from 10 μg/mL and100 μg/mL with 5 replicates would give precition and accuration. Precition was known from CV value and accuration was known from recovery value in each concentration. Liniearity was knownfrom regression linear between concentration and wide area of peak. From regresion linear couldcalculate LOD and LOQ. Research show that method of analyse have selectificity withRs= 2.27>1.5; liniearity with r= 0.99; precision with CV 8.74% at concentration 200 µg/mL and3.74% at concentration 500 µg/mL; accuration with recovery 99.76% at concentration 200 µg/mLand 100.52% at concentration 500 µg/mL and the value of LOD is 33.28 μg/mL and LOQ is110.93 μg/mL.
Co-Authors . Sismindari Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi Aditya Noviadi Rakhmatullah Afriyani, Neti Agung Putu S.P.Kristyawan Aina Fatkhil Haque, Aina Fatkhil Aji Pamungkas Alvionida, Fitra Amraini Amelia Ani Guntarti Any Guntarti Any Guntarti Astryna, Syarifah Yanti Atri Sri Ulandari Auliah Rahmi Latif Azis Ikhsanudin Bayu Herdi Al Huda Deasy Vanda Pertiwi Delia Komala Sari, Delia Komala Desrianti, Cindy Desyandri Desyandri Diah Pratimasari Diyan Sakti Purwanto Diyan Sakti Purwanto Endah Nurlaela Endah Nurlaela Endang Lukitaningsih Erma Pranawati ERMAWATI, DIAN EKA Erna Astuti Erna Astuti Erwin Fauzana Evi Nuryanti Fadzil Latifah Firsty, Girly Risma Fitra Alvionida Fitri Rahmawanti Fitriah Ardiawijianti Iriani Fudholi, Achmad Fudholi, Achmad Gina Lestari Gina Lestari, Gina Girly Risma Firsty Gita Puspita Hafid, Indah Fitria Hana Hanifah Hari Susanti Hari Susanti Heru Sasongko Ichwan Ridwan Rais Iis Wahyuningsih Jannah, Syauqul Kintoko Kintoko Kintoko, Kintoko Kurniawan, Muhammad Fariez Kusuma, Nyoman Rudi Laela Hayu Nurani Laila, Wahyu Kumil Lalu Muhammad Irham Lela Sulastri, Lela Lena Maulina Lena Maulina, Lena M Alif Fajri Marchaban . Miratun Syarifah Mohamad Ikram Muhammad Alfian, Muhammad Muhammad Fariez Kurniawan Muhammad Fariez Kurniawan Muhammad Yusron Maulana El-Yunusi Mukhlishah, Neneng Rachmalia Izzatul Nanik Sulistyani Nina Salamah NINGRUM, TYAS SARI RATNA Novitasari, Putri Rachma Nugrahini, Febrina Nurhayati Nurhayati Nuri Ari Efiana Nurlaela, Endah Olvia Becatami Widyantoro Olvia Becatami Widyantoro, Olvia Becatami Pertiwi, Deasy Vanda Pramono, Suwidjiyo Pramono, Suwidjiyo Puput Herawati Said Hasan Rahmat Hidayat Rahmawati, Desty Restia Raka Sukmabayu W.S Ratih Saridewi Rikadyanti Rikadyanti Rinanda Yeshi Wiradhika Ririn Suharsanti, Ririn Ristiono, Hendi Rosmiyanti, Yanti Rukaya, Benazir Evita Ryan Radix Rahadhian, Muhammad Sapto Yuliani Sapto Yuliani Sapto Yuliani Sismindari . Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari, Sismindari Sismindari, Sismindari Siti Athiyah Umaiyah Siti Ayu Marlina Sri Mulyaningsih Sri Mulyaningsih Srimuliani Arbie Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono. Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Teuku Nanda Saifullah, Teuku Nanda Trecya Fujiastuti Trecya Fujiastuti, Trecya Tusilowati, Defita Andri Ulfa Ramdhani M Uswatun Chasanah Vivi Sophia Waliyyin Razan Qanit wardhani, Riska risty Widyantoro, Olvia Becatami Widyasari Putranti Wisnu Kundarto Wuryandari, Tutik Wuryandari, Tutik Yayan Rizikiyan Zaenab Zaenab Zainab Zainab Zainab Zainab Zainab