Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Andi Rifki Rosandy (University Center of Excellence for Nutraceuticals, Biosciences and Biotechnology Research Center, Bandung Institute of Technology, Bandung, Indonesia 40132)
Sumail Sidik Ode Ishak (School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia 40132)
Noor Aziiraa Sabri (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43650 UKM Bangi, Selangor, Malaysia)
Wan Yaacob Wan Ahmad (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43650 UKM Bangi, Selangor, Malaysia)
Laode Muhammad Ramadhan Al Muqarrabun (School of Science UNSW Canberra at the Australian Defence Force Academy (ADFA), Canberra BC 2610, Australia)

Current Research on Biosciences and Biotechnology
Vol. 2 No. 2 (2021)

Dehaasia cuneata, locally known in Malaysia as ‘gajus hutan or pekan’, belongs to family Lauraceae. From its bark, A triterpenoid, lupeol was isolated and characterized. The chemical structure of the isolated compound was determined using spectroscopic methods, such as UV–vis, FT-IR, 1D & 2D-NMR, and ESIMS spectrometer. The isolated compound was tested against Gram-negative and positive bacteria using agar disc diffusion technique. The results showed that lupeol had a moderate inhibition zone value of 10.0±0.00 mm against Gram-negative Serratia marcescens ATCC 14756 whereas low inhibition which is 7.0±0.00 mm against Escherichia coli ATCC 25922, Vibrio fluvialis ATCC 33809, Bacillus subtilis ATCC 6633, and Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.