Higher IL-1beta level in the follicular liquid of endometriosis compared with non-endometriosis patients

Cahyono Hadi (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University, Indonesia)
Djaswadi Dasuki (Department of Obstetrics and Gynecology, Faculty of Medicine Gadjah Mada University)
Ahmad Hamim Sadewa (Department of Biochemistry, Gadjah Mada University)
Indwiani Astuti (Department of Pharmacotherapy, Molecular Biology, Faculty of Medicine Gadjah Mada University)
Awal Prasetyo (Department of Biomedical Science, Faculty of Medicine Diponegoro University)

Majalah Obstetri dan Ginekologi
Vol. 28 No. 2 (2020): August

Objective: To ascertain the IL-1b level in the follicular liquid of endometriosis sufferers compared with that of non-endometriosis sufferers.Materials and Methods: The ELISA method, for detecting the IL-1b, is taken from follicular fluid of endometriosis as well as non-endometriosis patients that diagnosed according to the ASRM criteria.Results: The 54 subjects were dominantly endometriosis <34 year old (88.9%).  The IL-1b levels of endometriosis patients and non-endometriosis patients were 82.86 ± 30.15 and 56.05 ± 23.27 respectively (p=0.01). The ROC value of IL-1b was found at a cut-off point of 26 (with the IL-1b cut-off point of 65.16). The discriminating value of AUC (area under curve) was 59.3%.Conclusion: It was concluded that the IL-1b level in endometriosis is higher than that in non- endometriosis.