Cross-Reaction Antibody Test between SARS-CoV-2 and Dengue Hemorrhagic Fever in Indonesia

Danny Luhulima (Faculty of Medicine, Christian University Indonesia, Jakarta/Mitra Keluarga Bekasi Timur Hospital, Jakarta)
Tri Soetowo (Mitra Keluarga Bekasi Timur Hospital, Jakarta)
Ria Amelia (STIKES Mitra Keluarga, Department of Laboratory Technology, Jakarta)

Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Vol 27, No 2 (2021)

Coronaviruses are a family of viruses that cause illness from the common cold to severe diseases such as Severe AcuteRespiratory Syndrome (SARS-CoV). In December 2019, forty new cases of pneumonia of unknown etiology have beenreported in Wuhan, China. The disease resembles Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and hasbeen subsequently named the 2019-novel Coronavirus Disease (COVID-19). The antibody test is a blood test that providesquantitative and qualitative detection of IgG and IgM antibodies against the SARS-CoV-2. Reported a male, 43-year oldsuffering from DHF, but the results of an IgG and IgM rapid test were COVID-19 reactive. Also, reviewed rapid tests forCOVID-19 and the results showed that only IgG was reactive. This explained that the patient already had SARS Cov-2antibodies but was not suffering from the disease. The rapid test COVID-19 IgM result was deemed to be a false positive.