<![CDATA[Lately, There have been many studies about salam leaf extract and chitosan nanoparticle 1% which have antibacterial potential on both gram-negative and gram-positive bacteria. Researchers interested for mixing two of ingredients use as an alternative antibacterial that will be more effective for future. The aims of study to determine the antibacterial potential salam leaf extract - chitosan nanoparticles 1% against the growth of Staphylococcus aureus. Salam leaf extract made by maceration method and converted into 50%, 75% and 100% concentrations, mixed with chitosan nanoparticles 1% ionic gelation method ratio 1 : 1 so there was three research groups. The antibacterial potensial tested by the disc diffusion method (Kirby-Bauer test). Based on one way ANOVA statistical, it showed significance value of p = 0,000 (p <0.05) so that means there was differences in the average diameter of inhibitory salam leaf extract 50%, 75% and 100% - chitosan nanoparticles 1% againt the growth of Staphylococcus aureus where is the results are 12.30 ± 0.2530 mm, 13.25 ± 0.3728 mm, 14.10 ± 0.1789 mm and reinforced by the Pearson correlation test. Thus the combination of 100% concentration salam leaf extract - chitosan nanoparticles 1% proved to be the most potential againt Staphylococcus aureus.]]>
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