Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Nunung Kurniasih (Department of Chemistry Faculty of Sciences and Technology Sunan Gunung Djati Islamic State University)
Asep Supriadin (Department of Chemistry Faculty of Sciences and Technology Sunan Gunung Djati Islamic State University)
Desi Harneti (Department of Chemistry Faculty Of Matheematics and Natural Sciences Universitas Padjadjaran)
Rizky Abdulah (Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Padjadjaran)
Mohamad Nurul Azmi bin Mohamad Taib (School of Chemical Sciences Universiti Sains Malaysia)
Unang Supratman (Central Laboratory Universitas Padjadjaran)

VALENSI
Jurnal Kimia VALENSI Volume 7, No. 1, May 2021

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.