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Nunung Kurniasih
Department of Chemistry Faculty of Sciences and Technology Sunan Gunung Djati Islamic State University
Chemistry

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Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines Nunung Kurniasih; Asep Supriadin; Desi Harneti; Rizky Abdulah; Mohamad Nurul Azmi bin Mohamad Taib; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.20068

Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.
Co-Authors Asep Supriadin Desi Harneti Putri Huspa Mohamad Nurul Azmi bin Mohamad Taib Rizky Abdulah Unang Supratman