Flavonoids from Macaranga lowii

Widiastuti Agustina (Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia)
Lia D. Juliawaty (Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia)
Euis H. Hakim (Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia)
Yana M. Syah (Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia)

Journal of Mathematical and Fundamental Sciences
Vol. 44 No. 1 (2012)

A new isoprenylated dihydroflavonol derivative, macalowiinin (1), together with two known flavonoids 4'-O-methyl-8-isoprenylnaringenin (2) and 4'-O-methyl-5,7,4'-trihydroxyflavone (3) (= acasetin), have been isolated from the methanol extract of the leaves of Macaranga lowii. The structures of these compounds were determined based on UV, NMR, and mass spectral data, and optical rotation. Preliminary cytotoxic evaluation of compounds 1 "“ 3 against P-388 cells showed that compound 3 is the most active with IC50 was 58.7 mM.