Journal of Mathematical and Fundamental Sciences
Vol. 10 No. 1 (1975)

Pengaruh Endoxan-Asta (Cyclophosphamide) pada Pertumbuhan Embryo Ayam

Sri Sudarwati (Departemen Biologi, Institut Teknologi Bandung)
Tien Wiati Suryono (Departemen Biologi, Institut Teknologi Bandung)



Article Info

Publish Date
04 Feb 2019

Abstract

Ringkasan. Telah diteliti pengaruh Endoxan-Asta (cyclophosphamide) terhadap pertumbuhan embryo ayam dengan jalan menyuntikkannya ke dalam kantung yolk pada umur 4 dan 5 hari inkubasi. Didapatkan, bahwa dosis teratogenic adalah 0.04 mg per telur. Malformasi yang ditimbulkannya adalah: gelembung meliputi mata, kelopak mata yang tidak tumbuh dengan sempurna, mata yang tidak tumbuh samasekali, paruh dengan sisi lateral yang bercelah, paruh bawah atau paruh atas yang pendek, paruh menyilang, micromelia, syndactyli, ectrodactyli, ectopia viscerum, exencephali dan "cleft palate". Selain itu Endoxan-Asta berpengaruh menghambat pertumbuhan pada umumnya. Abstract. The influence of Endoxan-Asta (Cyclophosphamide) on the development of chick embryos has been investigated by injecting the substance into the yolk sac of 4 and 5 days incubated eggs. It was found that 0.04 mg Endoxan-Asta per egg is a teratogenic dose. Malformations obtained during the investigation were: bulb over the eye, eyelids not well developed, undeveloped eyes, cleft on the lateral sides of upper beak, short upper or lower beak, crossed beak, micromelia, syndactyly, ectrodactyly, ectopia viscerum, exencephaly and cleft palate. Besides that, Endoxan-Asta caused stunted growth. 

Copyrights © 1975






Journal Info

Abbrev

jmfs

Publisher

Subject

Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics

Description

Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, ...