Jurnal Farmasi dan Sains Indonesia (JFSI)
Vol 4 No 1 (2021)

Pengaruh Pemberian Ekstrak Etanol Daun Dandang Gendis (Clinacanthus nutans (Burm F) Lindau) Terhadap Daya Analgetik Dan Gambaran Makroskopis Lambung Mencit

Maria Happy Christian Klau (Unknown)
Rosa Juwita Hesturini (Institut Ilmu Kesehatan Bhakti Wiyata Kediri)



Article Info

Publish Date
20 Jun 2021

Abstract

Dandang gendis (Clinacanthus nutans (Burm f.) Lindau) is one of the plants used for as medication for various type of illness. One of its uses is as an analgesic drug. This study aims to determine the effect of dandang gendis leaf extract on the analgesic activity and macroscopic image of the stomach of white rats. This research was conducted using a completely randomized unidirectional pattern. The creature used as treatment subjects were separated into five groups consists of five individual each: group I as negative control rats who were only given 1% Na-CMC equivalent, group II as positive control was given acetosal 500mg / KgBB, group III was given extract treatment with a dose of 450mg / KgBB, group IV was treated with the extract at a dose of 500mg / KgBB, group V was given an extract treatment at a dose of 550mg / KgBB. All groups were given acetic acid induction as a mediator of pain. The results showed that the ethanol extract of Dandang Gendis leaves had an analgesic effect and was safe to use as an analgesic at a dose of 500mg / KgBB.

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Journal Info

Abbrev

jfsi

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

Description

Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. ...