Spectral Analysis and In Vitro Biological Activity of Cu(II) Complex with Tridentate ONO Schiff Base Ligand

Emir Horozić (Faculty of Technology, University of Tuzla, Urfeta Vejzagića 8, 75 000 Tuzla, B&H)
Merima Ibišević (Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75 000 Tuzla, B&H)
Darja Husejnagić (Faculty of Natural Sciences and Mathematics, University of Tuzla, Urfeta Vejzagića 4, 75 000 Tuzla, B&H)
Enida Karić (Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75 000 Tuzla, B&H)
Nusreta Hasić (Faculty of Natural Sciences and Mathematics, University of Tuzla, Urfeta Vejzagića 4, 75 000 Tuzla, B&H)
Amina Hajdarević (Faculty of Technology, University of Tuzla, Urfeta Vejzagića 8, 75 000 Tuzla, B&H)

The Journal of Pure and Applied Chemistry Research
Vol 10, No 2 (2021): Edition May-August 2021

In this study, metal complex of Copper(II) with a Schiff base derived from 2,2-dihydroxyindane-1,3-dione and 2-aminoethanoic acid were synthesized. The product are characterized by spectral methods. The antimicrobial activity was tested on reference bacterial strains and the antioxidant capacity was analyzed by using the DPPH and FRAP methods. The spectral data indicates that the Schiff base coordinates the Copper(II) as a tridentate ONO donor ligand. The compounds showed weaker antimicrobial activity on certain tested microorganisms. In vitro testing of antioxidant activity showed a significant reducing ability of the complex, as well as inhibitory activity against DPPH radicals.