Increased Corticosterone Levels due to Chronic Stress Reduces IGF-II Expression in Rattus norvigecus

Ade Septiari Rahman
Reny I’tishom
Ashon Sa’adi

Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology

The optimal folliculogenesis process describes a good condition of the female reproductive system.One of the main growth factors in the folliculogenesis is IGF-II which is important for proliferation anddifferentiation of granulosa cells and also steroidogenesis. Chronic stress can cause ovulation failure andfolliculogenesis disorders. Increased corticosterone levels due to chronic stress will cause disruption in the