Synthesis and Characterization of New Oxo-Aztedine ,Imidazoldine and Thiazolidine Rings on Creatinine and Evaluation of their Biological Activity

RaadM.Muhiebes
Entesar O. AL-Tamimi

Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology

This work included preparation of new imine from the reaction of creatinine with aldehydes (4-nitrobenzaldehyde, 4- amino benzaldehyde, cinnamaldehyde) and ketone ( acetophenone ) in ethanol and thepresence of few drops glacial CH3COOH to obtain Schiff bases (1a,1b,1c,1d) Schiff bases were treatedwith monochloroacetyl chloride to produced (2a,2b,2c,2d), with glycine to synthesis (3a,3b,3c,3d) andwith 2-mercaptoacetic acid to prepare (4a,4b,4c,4d). The Prepared compounds had beenmeasured by (FTIR,and1HNMR ) spectroscopic techniques. Some of the derivatives were studied activity against antibacterial,antifungal and antioxidant.