Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology

Molecular Detection of BK Polyomavirus in Patients Under Hemodialysis

Eman Yousuf Rasheed (Unknown)
Fidan Ghanim Reshad (Unknown)
Muhannad Abdullah Allazzawy (Unknown)



Article Info

Publish Date
05 Sep 2021

Abstract

The study was conducted in Kirkuk city-Iraq from of February 2018 to September 2018. The numberof chronic kidney disease patients under study were 60 patients whose ages were between 40-70 yearsold. These patients admitted to Kirkuk general hospital (hemodialysis unit). The control group whowere matched to the patients studied, included 30 healthy blood donor and their ages were between 30-75 years old. Blood samples were collected for detection of BK polyomavirus DNA by real time-PCR.The study showed that the highest rate of BK polyomavirus DNA occurrence were recorded in patientswith chronic kidney disease when compared with control group (51.66% versus 3.33%) (P: <0.01).The study showed that the highest mean level of IL-6 was recorded in patients with chronic kidneydisease comparing with the control group (78.42 v.s. 3.40 ng/ml). The result was highly significant. Thepresent study demonstrated that the highest mean level of IL-6 was found in prostates cancer patientswho were positive to BK polyomavirus DNA comparing with BK polyomavirus DNA negative (52.54versus 25.88 ng/ml)It was concluded that BK polyomavirus was frequently detected in chronic kidney disease patients andcould play a relevant role in the development and progression of human hemodialysis

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