<![CDATA[Nickel in orthodontic bracket will be released immediately in the oral cavity. The release of Ni ion may trigger type IV hypersensitivity reaction. Colostrum has a high content of lactoferrin which can inhibit T cells proliferation after nickel sensitization, and decrease oxidative stress. Adding potassium sorbat 0.5%, or fermentation of colostrum may extend colostrum storage. The purpose of this research is to know the difference of nickel ion release in colostrum with 0.5% potassium sorbat addition and fermented colostrum. Methods of the study were laboratory experimental with four groups, colostrum and 0.5% potassium sorbat, fermented colostrum, sodium fluoride and artificial saliva. The sample was incubated in 40°C for 7 days. Nickel ions was measured using an inductively coupled plasma-optical emission spectrophotometry (ICP-OES Perlun Elmer Optima 8300®). Ni ions release differences were tested using the Kruskall-Wallis and Mann Whitney test.The lowest rate of Ni ion release wasfound in the colostrum group with 0.5% potassium sorbat followed by the fermented colostrum group. Kruskal-Wallis test no significant difference (p> 0,05) in each study group. The Mann Whitney test found significant differences between colostrum solution with 0.5% potassium sorbat and sodium fluoride, and also artificial saliva. The results concluded that colostrum with 0.5% potassium sorbat inhibit the release of Ni ions.]]>
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