Berkala Penelitian Hayati
Vol 16 No 2 (2011): June 2011

KAJIAN PRA-KLINIS PEMBERIAN ORAL BUBUK KERING-BEKU SUSU KEDELAI YANG DIFERMENTASI OLEH Lactobacillus plantarum AP1 DAN Sphingobacterium SP. TB17 PADA TIKUS

Achmad Dinoto (Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI))
Rita Dwi Rahayu (Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI))
Sri Purwaningsih (Pusat Penelitian Biologi, Lembaga Ilmu Pengetahuan Indonesia (LIPI))



Article Info

Publish Date
29 May 2012

Abstract

To investigate the effects of oral administration of freeze-dried soymilks fermented by Lactobacillus plantarum AP1 and Sphingobacterium sp. TB17, in preclinical study groups of male Sprague Dawley rats were fed for 3 weeks with four different test diets: basal diet (CD), basal diet supplemented with 3% (w/w feed) freeze-dried unfermented soymilk (CN), basal diet supplemented with 3% (w/w feed) freeze-dried soymilk fermented by L. plantarum AP1 (CL), and basal diet supplemented with 3% (w/w feed) freeze-dried soymilk fermented by Sphingobacterium sp. TB17 (CK). Our result showed a reduction of serum cholesterol level up to 15% in rats CB after three weeks consuming soymilk fermented by L. plantarum AP1. This yield was relatively higher than that of rats CK consuming soymilk fermented by Sphingobacterium sp. TB17 to reduce serum cholesterol only up to 5%. Although unfermented soymilk (CN) also showed the hypocholesterolomic effect to rats, the reduction of cholesterol serum level was lower than that of rat CL. There were no signifi cant increased in blood glucose and body weight of rats as impact of freeze-dried fermented soymilk. Interestingly, although feed intake tends to increase during fermented soymilk consumption, the body weight of rats did not increase. In general, this study indicated that L. plantarum AP1 soymilk is a promising beneficial food product for the health.

Copyrights © 2011






Journal Info

Abbrev

jurnal

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Description

Berkala Penelitian Hayati is a half yearly international peer reviewed, an open access life science journal. The journal was published by The East Java Biological Society and formerly used the Indonesian language. The first edition of this journal is Vol 1 No 1 in June 1995. It was accredited by ...