Jurnal Farmasi Sains dan Komunitas
Vol 11, No 1 (2014)

SINTESIS ASAM SINAMAT DARI BENZALDEHIDA DAN ASAM MALONAT DENGAN KATALIS DIETILAMINA

Jeffry Julianus (Fakultas Farmasi Universitas Sanata Dharma)
Elvan Luckyvano (Unknown)



Article Info

Publish Date
29 Mar 2016

Abstract

Abstract: Cinnamic acid is a natural compound that has known had activities as: antimicrobia; flavour in food; soap; cosmetic; and inhibitor proliferation of caco-2 cells. Cinammic acid compound commonly got by isolated kayu manis bark with yield 2.2%. There was a limitation amount of cinnamic acid that got by isolation so needed another effort to get much amount of cinnamic acid. There was an effort to get much amount of cinnamic acid that was by synthesized it. Synthesis process was carried out by reacted benzaldehyde 45 mmol (4.9 g) and malonic acid 45 mmol (4.5 ml) with catalyzed dietylamina for 7.5 hours at 80OC. Synthetic compound was carried out organoleptic test, solubility test, melting point test, gas chromatography, structure elucidation with ultraviolet spectrophotometry, infrared spectrophotometry, nuclear magnetic resonance spectroscopy (1H-NMR), mass spectroscopy; and amount of yield. Synthetic compound was white smooth crystal powder, and had a specific flavour with yield was4.68% and melting point was 132-133OC. Solubility test showed the synthetic compound dissolved in ethanol, methanol, chloroform, dimethyl sulfoxide, hot water, and acetone; very difficult soluble in water. Gas chromatography chromatogram showed one peak with retention time 13.321 minute. Based on structure elucidation conclude that synthetic compound was cinnamic acid.

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Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...