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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry JURNAL PENGABDI Rengganis Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacology and Therapy

Jeffry Julianus

Fakultas Farmasi Universitas Sanata Dharma

Author-ID : 3661137

Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Energy Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences

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Articles

DESAIN DAN SINTESIS SENYAWA ACES (ANALOG CURCUMIN SERIES) DENGAN METODE SOLID PHASE REACTION SEBAGAI SENYAWA ANTIKANKER POTEN DENGAN MEKANISME MENGHAMBAT PROTEIN NF-kB Monica Sabrina Widiapranolo; Eva Mayangsari; Venny Valeria; Jeffry Julianus
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: Analog of curcumin in forms of enone and dienone aromatic is known for their activityas an NF-?B inhibitor. In this study, will be synthesize 2-(4'-N, N-dimethylamino benzilidine)cyclohexane-1,3-dione as an analog that predicted has an activity as an NF-?B inhibitor. Thisresearch was conducted based on the crossed aldol condensation reaction by reacting 3 mmole pN,N-dimethylamino benzaldehide and 6 mmole cyclohexane-1,3-dione with hydrochloric acid asthe catalyst using solid phase reaction method. Based on computational analysis, 2-(4'-N,Ndimethylamino benzilidine) cyclohexane-1,3-dione showed a better interaction with NF-?Bprotein with PLANTSPLP score was -69,7895. The outcome of the reaction was yellow coloredpowder, no odor and soluble in hydrochloric acid 3N. The yield value was 78.8%. Liquidchromatography showed 100% purity. The melting point range was 237.5-240.3C. The resultsof structure elucidation by 1H-NMR, infrared and mass spectroscopy tests indicated thecompound was 2-(4-(dimetilamino)benzilidena)-4-(3-oksosiklohex-1-enil) sikloheksana-1,3-dion.Key words: 2-(4'-N, N-dimethylamino benzilidine) cyclohexane-1,3-dione, crossed aldolcondensation, solid phase reaction.

SINTESIS ASAM SINAMAT DARI BENZALDEHIDA DAN ASAM MALONAT DENGAN KATALIS DIETILAMINA Jeffry Julianus; Elvan Luckyvano
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Cinnamic acid is a natural compound that has known had activities as: antimicrobia; flavour in food; soap; cosmetic; and inhibitor proliferation of caco-2 cells. Cinammic acid compound commonly got by isolated kayu manis bark with yield 2.2%. There was a limitation amount of cinnamic acid that got by isolation so needed another effort to get much amount of cinnamic acid. There was an effort to get much amount of cinnamic acid that was by synthesized it. Synthesis process was carried out by reacted benzaldehyde 45 mmol (4.9 g) and malonic acid 45 mmol (4.5 ml) with catalyzed dietylamina for 7.5 hours at 80OC. Synthetic compound was carried out organoleptic test, solubility test, melting point test, gas chromatography, structure elucidation with ultraviolet spectrophotometry, infrared spectrophotometry, nuclear magnetic resonance spectroscopy (1H-NMR), mass spectroscopy; and amount of yield. Synthetic compound was white smooth crystal powder, and had a specific flavour with yield was4.68% and melting point was 132-133OC. Solubility test showed the synthetic compound dissolved in ethanol, methanol, chloroform, dimethyl sulfoxide, hot water, and acetone; very difficult soluble in water. Gas chromatography chromatogram showed one peak with retention time 13.321 minute. Based on structure elucidation conclude that synthetic compound was cinnamic acid.

SYNTHESIS AND PHYSICOCHEMISTRY PROPERTIES PREDICTION OF A NEW POTENTIAL ANTI-INFLAMMATORY AGENT: DIACETYL PENTAGAMAVUNON-1 Supardjan A. Margono; Pudjono Pudjono; St. Layli Prasojo; Jeffry Julianus; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

Synthesis and physicochemistry properties prediction of a potential anti-inflammatory agent, diacetyl pentagamavunon-1 (diacetyl PGV-1), has been done. The synthesis was using pentagamavunon-1 (PGV-1) (2,87x10-3 mole) and anhydride acetic acid (26x10-3 mole; 37x10-3 mole; 49x10-3 mole) as starting materials and NaOH ethanolic as a catalyst. The AM1 semiempirical quantum-chemical calculations using the computational chemistry approach was used to predict and compare the physicochemisty properties of diacetyl PGV-1 to PGV-1. Odorless, light-yellow powder has been obtained. The powder was 0.8512-0.9602 g (2.02 x10-3 - 2.22x10-3 mole; 70.4-77.4%) and the purity of the powder was 92.4%. The purity of the product has been examined by high performance liquid chromatography (HPLC), while the structure elucidation has been done using IR (Infra Red), 1H-NMR (Nuclear Magnetic Resonance) and MS (Mass Spectroscopy). The physicochemisty properties prediction showed that diacetyl PGV-1 was more hydrophobic than PGV-1.

In vitro and in vivo anti-hyperglycemia effects of extract of Faloak (Sterculia quadrifida R.Br.) leaves Andrestia Dias, Velia; Celine Dinanda, Laurenza; Conrad Rambung, Charles; Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Maria; Julianus, Jeffry; Hendra, Phebe
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28263

Despite the availability of various conventional treatments, diabetes mellitus remains a serious global health concern with an increasing prevalence. This trend underscores the need to explore potential natural alternatives. Faloak, an indigenous plant of Indonesia, has been traditionally used for various health conditions, yet its potential as an anti-hyperglycemic agent has not been comprehensively investigated. This research focused on identifying the ingredients of Faloak leaves that could lower blood sugar levels and confirm these effects in laboratory and animal models. At various concentrations, the in vitro evaluation assessed the inhibitory effect of α-amylase and α-glucosidase enzymes. For in vivo evaluation, male mice were administered glucose, sucrose, and starch after being pretreated with Faloak leaf extract, and their blood glucose levels were monitored for 120 min. Faloak leaf extract demonstrated significant inhibitory activity against α-amylase and α-glucosidase enzymes. The IC50 values for sucrose and maltose inhibition were 30.37 and 65.36 mg/mL, respectively, while α-amylase inhibition showed an IC50 of 27.02 mg/mL. In the in vivo test, mice pretreated with the extract exhibited significantly decreased blood glucose levels at 120 min compared to the control group. These findings indicate that the ethanolic extract of Faloak leaves possesses promising anti-hyperglycemic activities, positioning it as a potential candidate for developing plant-based blood glucose management. Our results demonstrate that Faloak leaf extract exhibits substantial anti-hyperglycemic properties, inhibiting vital digestive enzymes and effectively reducing postprandial glucose levels. Identifying active ingredients paves the way for further research to elucidate specific bioactive compounds and their mechanisms of action

Edukasi Hipertensi pada Pasien PROLANIS Puskesmas Wonosari II Hendra, Phebe; Pramono, Zita Dhirani; Julianus, Jeffry; Riswanto, Florentinus Dika Octa
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.85251

Hipertensi merupakan salah satu penyakit yang menjadi penyebab kematian terbanyak di dunia. Pengendalian hipertensi dapat dilakukan dengan berbagai cara. BPJS Kesehatan telah menetapkan PROLANIS (Program Pengelolaan Penyakit Kronis) sebagai salah satu program yang ditujukan untuk pasien dengan penyakit kronis. Puskesmas Wonosari II merupakan salah satu layanan primer yang mengadakan program PROLANIS secara rutin. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada peserta PROLANIS terkait penyakit hipertensi melalui media booklet. Kegiatan ini diselenggarakan atas kerjasama dari tim dari Fakultas Farmasi Universitas Sanata Dharma dan Puskesmas Wonosari II. Sebanyak 26 peserta menghadiri kegiatan edukasi yang bersamaan dengan kegiatan rutin yakni senam PROLANIS. Adanya edukasi melalui media booklet ini diharapkan dapat meningkatkan kualitas hidup dan mengontrol tekanan darah pasien.

One-Pot Synthesis and In Vitro Studies of Calix[4]-2-methylresorcinarene Derivatives as Antimalarial Agents Against Plasmodium falciparum Chloroquine-Resistant Strain FCR-3 Nursofia, Baiq Ike; Kurniawan, Yehezkiel Steven; Jumina, Jumina; Pranowo, Harno Dwi; Sholikhah, Eti Nurwening; Julianus, Jeffry; Wibowo, Susalit Setya; Fatimi, Hana Anisa; Priastomo, Yoga; Priyangga, Krisfian Tata Aneka
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.94885

Malaria is an endemic disease in Indonesia caused by infection from the Plasmodium parasite. Recently, antimalarial resistance significantly contributed to the decline in the cure rate of malaria sufferers. In this work, three calix[4]resorcinarenes have been synthesized from 2-methylresorcinol and different benzaldehyde derivatives, i.e., 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, and 4-dimethylaminobenzaldehyde through the one-pot synthesis procedure. The calix[4]resorcinarenes synthesis was done through a cyclo-condensation reaction by using HCl 37% as the catalyst and ethanol as the solvent in an one-pot reaction. The structures of the synthesized products were confirmed using Fourier transform infrared, proton-nuclear magnetic resonance, and liquid chromatography-mass spectrometry techniques. The antimalarial activity assay was evaluated against the Plasmodium falciparum FCR-3 strain through an in vitro study. Three synthesized compounds, i.e., C-4-chlorophenylcalix[4]-2-methylresorcinarene, C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene have been successfully synthesized in up to 97% yield. The C-4-chlorophenylcalix[4]-2-methylresorcinerene exhibited the most potent antimalarial activity with a half-maximal inhibitory concentration (IC50) value of 2.66 µM against P. falciparum FCR-3 while the C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene gave the IC50 values of 23.63 and 13.82 µM, respectively. From the results, it could be concluded that the antimalarial activity of calix[4]-2-methylresorcinarenes was influenced by the type of substituent of aromatic rings at the para position.

Pemberdayaan Kesehatan Masyarakat Dusun Kemantren II Semawung Melalui Edukasi Pengelolaan Obat Hendra, Phebe; Riswanto, Florentinus Dika Octa; Setyani, Wahyuning; Julianus, Jeffry; Rajagukguk, ⁠Greysianita; Santi , Nyoman Pradnya Yoni Meytri; Bramantyo , Dominicus Adyatma; Siallagan , Angela Meirella; Putri , Elsha Tiany
Rengganis Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): November 2025
Publisher : Pendidikan Matematika, FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/rengganis.v5i2.608

The misuse of drugs is a major health issue in Indonesia, largely due to a lack of understanding about proper drug management. Knowledge of correct medication use is essential to prevent administration errors. Key issues in Dusun Kemantren II, Semawung Village include a limited understanding of medication usage and inadequate drug storage systems. Engaging the community with information on effective drug management is essential to address this. This community service initiative aims to improve drug management knowledge in Dusun Kemantren II, Semawung Village, Purworejo District. The activity was carried out on May 4, 2025, with 23 participants. Evaluation results showed increased participants' knowledge after the education, based on average pre-test and post-test scores. This program successfully improved public knowledge and awareness regarding the importance of proper drug management. It provided practical means, such as medicine boxes, to support the implementation of this knowledge at the household level.

Synthesis of 3-carbethoxy-4(3’-chloro-4’-hydroxy) phenyl-but-3-en-2-one and its cytotoxicity evaluation against cancer cell carrying mutant p53 Julianus, Jeffry; Mustofa; Jumina
Indonesian Journal of Pharmacology and Therapy Vol 2 No 1 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1211

Overexpression of mutant p53 in cancer cell inactivates the p53 pathways to execute apoptosis and cell cycle arrest. This study aimed to synthesize new kardiena derivative compound, 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one, to reactivate the p53 pathways to execute apoptosis and cell cycle arrest. Characterization of the synthetic compound employing melting point, IR, EI-MS, 1H-NMR, and 13C-NMR spectra revealed 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one was successfully synthesized from 3-chloro-4-hydroxybenzaldehyde and ethyl acetoacetate using dimethylamine as a catalyst. This compound had antiproliferative activity against the WiDr cells which carried mutant p53. Its antiproliferative activity was better than 5’-FU as a reference standard to treat colon cancer. Increasing WiDr cell accumulation in the G2-M phase, the active form of caspase-3, and inducing apoptosis demonstrated the ability of 3-carbethoxy-4(3’-chloro-4’-hydroxy)phenyl-but-3-en-2-one to reactivate p53 pathways to execute apoptosis and cell cycle arrest in cancer cells carrying mutant p53.

Molecular docking study of Indonesian phytochemicals as inhibitor of 6-HB formation by binding to HR1 subunit of SARSCOV-2 S2 protein Julianus, Jeffry; Phebe Hendra; Maywan Hariono; Nico Frederick; Satrio Ardyantoro; Mustofa; Jumina
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2392

Coronavirus disease 2019 (COVID-19) is still as global pandemic. No officially drugs to treat COVID-19 are available until now. Increasing number of patients and deaths trigger new antiCOVID-19 discovery efforts. In this study, we have conducted in silico screening employing molecular docking for Indonesian phytochemicals. Docking process was performed by employing AutoDock4 software on crystal structure 6VSB. Based on molecular docking results, several compounds had potential as antiCOVID-19 drugs, such as β-carotene, veramiline, ecliptalbine, betulinic acid, and lupeol. β-carotene was the most potential compound to treat COVID-19.

Co-Authors Andrestia Dias, Velia Bramantyo , Dominicus Adyatma Celine Dinanda, Laurenza Conrad Rambung, Charles Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Maria Elvan Luckyvano Enade Perdana Istyastono Eti Nurwening Sholikhah Eva Mayangsari Fatimi, Hana Anisa Florentinus Dika Octa Riswanto Harno Dwi Pranowo Jumina Jumina Jumina Jumina Kurniawan, Yehezkiel Steven Maywan Hariono Monica Sabrina Widiapranolo Mustofa Mustofa Mustofa Nico Frederick Nico Frederick Nursofia, Baiq Ike Phebe Hendra Phebe Hendra Phebe Hendra, Phebe Pramono, Zita Dhirani Priastomo, Yoga Priyangga, Krisfian Tata Aneka Pudjono Pudjono Putri , Elsha Tiany Rajagukguk, ⁠Greysianita Santi , Nyoman Pradnya Yoni Meytri Satrio Ardyantoro Satrio Ardyantoro Siallagan , Angela Meirella St. Layli Prasojo Supardjan A. Margono Venny Valeria Wahyuning Setyani Wibowo, Susalit Setya

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