Cendekia Journal of Pharmacy
Vol 5, No 2 (2021): Cendekia Journal of Pharmacy

THE EFFECTIVENESS TEST OF CIPLUKAN (Physalis angulate L.) LEAF EXTRACT ON WOUND HEALING IN MALE RABBIT (Oryctolagus cuniculus) WISTAR STRAIN

Baiq Mahmudah (Universitas Nahdlatul Ulama NTB)
Recta Olivia Umboro (Universitas Bumigora)
Fitri Apriliany (Universitas Bumigora)



Article Info

Publish Date
30 Nov 2021

Abstract

  An incision wound is a wound that occurs because of a sharp incision on the skin. This wound can occur in the dermis and epidermis of the skin with a depth 0,3cm, and length of 1,5cm. If not handle properly, the cut can develop into an infected wound. Ciplukan leaves (Physialis angulata L.) contain tannins compounds. Tanin compound can accelerate wound healing with cellular mechanism. The purpose of this study is to determine the ability of ciplukan leaves extract as an alternative medicine in healing the incisions.This study is an experimental study using a completely randomized design wich using 3 treatment groups of male rabbit (Oryctolagus cuniculus) consisted of: 1st group  negative control (vaselin flava), 2nd group positive control (povidone iodine), 3rd group ciplukan leaves extract test with 3 different concentrations (15%, 30%, 45%). Wound healing was observed for 20 days.The results of the analysis using One-way ANOVA, Kruskal Wallis obtained a value of p?0.05, showed the extract of ciplukan leaves is effective in healing incisions . The healing ability equivalent to positive control with a healing time of 13 days was shown at a concentration of 45%. 

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Journal Info

Abbrev

cjp

Publisher

Subject

Medicine & Pharmacology

Description

Cendekia Journal of Pharmacy published by the Program Studi Farmasi STIKES Cendekia Utama Kudus with registered number ISSN 2599-2163 (Print) and for ISSN (Online) is 2599-2155. This journal is published twice a year, in November and May. ...